The Centre for Research Excellence in Sun and Health (CRESH) aims to build an evidence base that will lead to the development of regionally appropriate public health guidelines that will balance the adverse and beneficial effects of sun exposure to optimise the health of the Australian community.
There is a need for a greater understanding of the complex relationship between sun exposure and the production of Vitamin D. This study will expand on the recently-completed AusD study to examine how personal, behavioural, and environmental factors impact on intra-individual seasonality in Vitamin D production. The study findings will guide the development of specific, evidence-based public health recommendation that balance the risks and benefits of sun exposure.
Squamous cell carcinoma of the skin is extremely common in Australia, resulting in disfiguring surgeries and deaths. Although cumulative sun exposure is important, some people are very susceptible, and we do not know why. This project hinges on the notion that skin cancer is a complex (many genes involved). We will utilize novel systems to harness this complexity to understand why some people are resistant and others very susceptible so as to design appropriate control measures and treatments.
Fighting Epidermal Skin Cancers By Targeting Epidermal Clones That Accumulate Mutations
Funder
National Health and Medical Research Council
Funding Amount
$1,149,373.00
Summary
Common skin cancers such as basal and squamous cell carcinomas (BCC and SCC) are by far the most frequent cancer worldwide and require over a million interventions per year in Australia. This project will identify the skin cells that are most susceptible to give rise to cancer if excessively exposed to the sun and explores ways to prevent cancer formation. This will inform on new strategies to prevent new skin cancer development.
Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Quantitiative Assessment Of Solar UV Exposure For Vitamin D Synthesis In Australian Adults
Funder
National Health and Medical Research Council
Funding Amount
$1,162,536.00
Summary
This research program will add significantly to our current scientific understanding of the dual health outcomes of UV exposure (Vitamin D and skin cancer) . This project is in line with Australia's R and D Priorities, in that it will result in direct and indirect social and economic benefits to Australia by applying the scientific knowledge gained through this research to develop public health initiatives to improve some of Australia's most significant and costly health problems.
Telerehabilitation: Assessing Acquired Neurogenic Communication Disorders Online.
Funder
National Health and Medical Research Council
Funding Amount
$172,446.00
Summary
People who suffer brain damage as a result of a stroke, head injury, or a disorder such as Parkinson's disease frequently develop difficulty in either speaking, writing, reading, or understanding the spoken language. As a result, the person's ability to communicate with his or her family and friends, and the community in general is seriously affected. Individuals who experience these speech and language disorders are treated by a speech pathologist who focuses on improving the person's ability t ....People who suffer brain damage as a result of a stroke, head injury, or a disorder such as Parkinson's disease frequently develop difficulty in either speaking, writing, reading, or understanding the spoken language. As a result, the person's ability to communicate with his or her family and friends, and the community in general is seriously affected. Individuals who experience these speech and language disorders are treated by a speech pathologist who focuses on improving the person's ability to communicate. The treatment of these disorders is frequently long-term requiring speech pathology management beyond existing hospital care. For many people with these communication disorders, accessing speech pathology services after their discharge from hospital may be very difficult due to their physical difficulties, the distances they are required to travel, and the limited availability of speech pathologists in their local community. This project aims to overcome these access issues through the development of a telerehabilitation system that will enable speech pathologists to assess people with these speech and language difficulties across the Internet using videoconferencing. It is intended that this research will ultimately enable people with these types of communication difficulties to be assessed and treated within their own home or local community.Read moreRead less