The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, ....The Centre will enhance Australian clinical immunisation research and training, focussing upon clinical questions with translatable outcomes not easily addressed by industry. Optimal immunisation and interventions to maximise uptake of existing and new vaccines in high risk patient groups, such as children with cancer, immigrants, children with chronic diseases and adolescents will be studied. New vaccine trials, innovative use of existing vaccines, systematic collection of vaccine failure data, and targeted epidemiology and disease modelling vaccine preventable disease will also allow a broad program of research, enabling training and mentoring of young clinical nurse and physician researchers. Collaborations with existing national immunisation, infectious diseases and research institutions will allow maximal effectiveness of clinical studies.Read moreRead less
Generation Of Protective Immunity Against Severe Influenza Disease In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$1,630,970.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Aus ....Amplifying Indigenous news: a digital intervention. This project aims to road-test, document and analyse an innovative strategy for amplifying Indigenous voices in news media. The project will deploy and assess the impact of a new digital application designed to enable access to a diverse range of Indigenous voices, stories and agendas. The anticipated outcomes will assist the project’s industry partners meet their strategic goals of increasing the level of Indigenous media representation in Australia, and consolidate their roles as leading outlets for Indigenous content and coverage. These outcomes are also expected to improve public understanding of issues affecting Indigenous Australians and contribute to more informed and inclusive policy discussions.Read moreRead less
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.
Creative Tropical City: Mapping Darwin's Creative Industries. This research will improve our knowledge and understanding of the creative industries in Darwin. It will provide a strong evidence base for the development of policy options for growing the creative industries in Darwin. And it will interrogate national and international creative industry policy frameworks for their applicability to Darwin.
Discovery Indigenous Researchers Development - Grant ID: DI0775813
Funder
Australian Research Council
Funding Amount
$70,000.00
Summary
Bringing indigenous knowledge into early childhood settings. This project will produce a negotiated model of Indigenous teaching and learning in early childhood settings by documenting the diversity of Indigenous knowledge from the Northern Territory. This model will be suitable for sharing with Indigenous and non-Indigenous children within the early childhood sector. Through this sharing there can be a greater recognition and acceptance of the knowledge Indigenous children bring to early chil ....Bringing indigenous knowledge into early childhood settings. This project will produce a negotiated model of Indigenous teaching and learning in early childhood settings by documenting the diversity of Indigenous knowledge from the Northern Territory. This model will be suitable for sharing with Indigenous and non-Indigenous children within the early childhood sector. Through this sharing there can be a greater recognition and acceptance of the knowledge Indigenous children bring to early childhood programs, a facilitation of understanding in non-Indigenous children and assist in the maintenance of this knowledge for future generations. Read moreRead less
The Visual Mediation of a Complex Narrative: TGH Strehlow's Journey to Horseshoe Bend. TGH Strehlow's biographical memoir, Journey to Horseshoe Bend, is a vivid ethno-historiographic account of Aboriginal, settler and Lutheran communities of Central Australia in the 1920's. This project intends to construct an extensive digital hub elaborating key textual thematics of Aboriginal identity and sense of ?place?, supplemented with oral histories. Consistent with the Strehlow Research Centre's missio ....The Visual Mediation of a Complex Narrative: TGH Strehlow's Journey to Horseshoe Bend. TGH Strehlow's biographical memoir, Journey to Horseshoe Bend, is a vivid ethno-historiographic account of Aboriginal, settler and Lutheran communities of Central Australia in the 1920's. This project intends to construct an extensive digital hub elaborating key textual thematics of Aboriginal identity and sense of ?place?, supplemented with oral histories. Consistent with the Strehlow Research Centre's mission in the management and preservation of the Strehlow Collection's vast archival materials, the project will provide access to and foster engagement with Strehlow's works. The project will employ innovative visual methodologies in the production and mediation of Indigenous knowledge related to the text. Read moreRead less
Can there be good policy? Tracing the paths between policy intent, evidence and practical benefit in regional and remote Australia. By tracking major health, housing and education reforms currently underway across regional and remote Australia, this research generates fresh perspectives on an urgent contemporary debate in Indigenous social affairs: namely, are governments best placed to drive social change or to determine policy imperatives; and if not, are there alternate ways to generate good ....Can there be good policy? Tracing the paths between policy intent, evidence and practical benefit in regional and remote Australia. By tracking major health, housing and education reforms currently underway across regional and remote Australia, this research generates fresh perspectives on an urgent contemporary debate in Indigenous social affairs: namely, are governments best placed to drive social change or to determine policy imperatives; and if not, are there alternate ways to generate good policy? An anthropological approach will be used to observe government policy at work. The research will explore the institutional reasons behind the gap between intention and outcome in Indigenous social policy; how failure cycles in policy are replicated; and possible techniques for creating and implementing a new ethics of policy engagement.Read moreRead less