Wicked defaults: how to overcome the dark side of choice architecture. This project aims to investigate how defaults and product complexity might be used to exploit consumers in environments like private insurance where consumers are prone to making systematic errors. Defaults are used to nudge individuals into socially beneficial actions such as increasing their retirement savings and joining organ donor lists. However, in the hands of firms, defaults can also be used to exploit consumers by en ....Wicked defaults: how to overcome the dark side of choice architecture. This project aims to investigate how defaults and product complexity might be used to exploit consumers in environments like private insurance where consumers are prone to making systematic errors. Defaults are used to nudge individuals into socially beneficial actions such as increasing their retirement savings and joining organ donor lists. However, in the hands of firms, defaults can also be used to exploit consumers by encouraging choices that help the firm but disadvantage consumers. The project intends to study experimentally whether exploitation can be reduced via competition and reputation building systems based on consumer feedback.Read moreRead less
Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the internati ....Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the international standing of Australia in the field. The project will provide a high level of training and expertise for Australia-based chemists.Read moreRead less
Architectural Design Across Spaces and Cultures: Technology and Language. This project addresses two significant productivity barriers facing Australia’s architectural practices; designing in spatially distributed and culturally diverse teams.
While design practices are central to sustaining Australia’s creative export sector, growing concerns associated with online, multilingual design teams have been identified.
Directly responding to Australia’s COVID-19 recovery plans, this research seeks ....Architectural Design Across Spaces and Cultures: Technology and Language. This project addresses two significant productivity barriers facing Australia’s architectural practices; designing in spatially distributed and culturally diverse teams.
While design practices are central to sustaining Australia’s creative export sector, growing concerns associated with online, multilingual design teams have been identified.
Directly responding to Australia’s COVID-19 recovery plans, this research seeks to develop new knowledge about the cognitive, social and technical factors that shape the effectiveness of online international design teamwork. Its goal is to leverage the opportunities provided through technological advances and multicultural practices, to remove barriers to design productivity and enhance creativity.Read moreRead less
A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelli ....A Mathematical Model of the Roles of Contraction and Oxygen in Human Wound Healing. Slow or impaired wound healing and excessive scarring associated with burns are both painful and costly. Moreover, the debilitating effect of chronic wounds can be expected to increase with the continuing aging of the population and the current rise in incidence of Type 2 diabetes. This project brings together a multidisciplinary team to develop a mathematical model of human wound healing and to drive the modelling to generate important breakthroughs at the level of basic science with implications for both experimentalists and clinicians.Read moreRead less
Prior sensitivity analysis for Bayesian Markov chain Monte Carlo output. This project aims to develop the first set of techniques to implement an automated output sensitivity analysis for Markov Chain Monte Carlo (MCMC) estimation methods. Computationally intense Bayesian MCMC provide a powerful alternative to classical methods for the estimation of economic models. An obstacle to their wider application is that researchers need to specify prior beliefs about model parameters that will affect t ....Prior sensitivity analysis for Bayesian Markov chain Monte Carlo output. This project aims to develop the first set of techniques to implement an automated output sensitivity analysis for Markov Chain Monte Carlo (MCMC) estimation methods. Computationally intense Bayesian MCMC provide a powerful alternative to classical methods for the estimation of economic models. An obstacle to their wider application is that researchers need to specify prior beliefs about model parameters that will affect the results. The expected outcomes will enable researchers to undertake a routine assessment of the sensitivity of the results to prior inputs.Read moreRead less
The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions th ....The RGG/RG motif as an RNA chaperone: advancing CRISPR-Cas RNA technology. This project investigates the way in which protein molecules interact effectively with RNA molecules and also aims to enhance the CRISPR-Cas13a system for RNA detection. Innovative approaches will be used to test the role of a particular protein motif, called the RGG/RG motif, in remodelling RNA structure and enhancing the Cas13a protein. This knowledge is expected to shift our understanding of protein-RNA interactions that are fundamental to almost every aspect of cell biology. The project is intended to benefit Australia through contributing to fundamental knowledge in the field, facilitating the development of new CRISPR-Cas biotechnologies for RNA detection and through the training of young researchers in frontier technologies. Read moreRead less
New approaches for testing in nonlinear models. The outcome of this project is a new econometric methodology that will be particularly useful for developing our understanding of Australian (and global) financial markets. Specific benefits are that (i) our value-at-risk models will enhance national and international awareness of issues relating to financial risk management; (ii) our exchange rate pass through model will aid the development of Australian trade and pricing policies and (iii) our du ....New approaches for testing in nonlinear models. The outcome of this project is a new econometric methodology that will be particularly useful for developing our understanding of Australian (and global) financial markets. Specific benefits are that (i) our value-at-risk models will enhance national and international awareness of issues relating to financial risk management; (ii) our exchange rate pass through model will aid the development of Australian trade and pricing policies and (iii) our duration models for trade in Australian stocks will lead to a better understanding of the microstructure of the Australian stock market.Read moreRead less
Photodissociation mass spectrometry for lipidome analysis. This project aims to develop and apply novel bioanalytical mass spectrometry-based methods and workflows to illuminate the otherwise hidden structural diversity and molecular complexity of the lipidome. The structure of individual lipids define their specific biological functions. A major requirement of analytical methods employed for lipid analysis on a lipidome-wide scale, therefore, is to enable the detailed structural characterisatio ....Photodissociation mass spectrometry for lipidome analysis. This project aims to develop and apply novel bioanalytical mass spectrometry-based methods and workflows to illuminate the otherwise hidden structural diversity and molecular complexity of the lipidome. The structure of individual lipids define their specific biological functions. A major requirement of analytical methods employed for lipid analysis on a lipidome-wide scale, therefore, is to enable the detailed structural characterisation of the, potentially, tens of thousands of individual molecular lipid species that may be present within a sample of interest. This project will develop and optimise novel, ultraviolet photodissociation-tandem mass spectrometry methods which will be integrated within an automated lipidome analysis workflow, to enable comprehensive global lipidome profiling and to reveal the structural diversity of lipids involved in fundamental cellular signalling processes.Read moreRead less
Robust methods for heteroscedastic regression models for time series. What is the variability of the exchange rate of the Euro to the Australian dollar? Can the use of the electrocardiogram of a patient be improved as a diagnostic tool for heart disease? A well-known limitation of the existing statistical methods for answering these types of questions is that a small proportion of extreme observations have the potential to lead to results that are more in agreement with the outliers than with bu ....Robust methods for heteroscedastic regression models for time series. What is the variability of the exchange rate of the Euro to the Australian dollar? Can the use of the electrocardiogram of a patient be improved as a diagnostic tool for heart disease? A well-known limitation of the existing statistical methods for answering these types of questions is that a small proportion of extreme observations have the potential to lead to results that are more in agreement with the outliers than with bulk of the data. As a consequence, the statistical analyses may lead to wrong conclusions. This project aims to develop new methodologies to solve this problem for a large class of studies. Applications to stock market risk, exchange rate, and diagnosis of heart diseases will illustrate the new methods.Read moreRead less