Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automate ....Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automated classification and de-obfuscation technologies are a precondition to applying more sophisticated detection heuristics. The project will be instrumental in safeguarding Australia by protecting critical infrastructure and defending us from online organised crime and information warfare.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Gigabit Wireless: Setting the Standard for Tomorrow's Broadband. This project will strengthen a long-term alliance between researchers at the University of Melbourne and NEC Australia, one of the few multinational research laboratories with significant R & D presence in Australia. Researchers at the University of Melbourne with expertise in communication theory fundamentals will collaborate with experienced research and design engineers at NEC, to produce fundamental research, and the resulting ....Gigabit Wireless: Setting the Standard for Tomorrow's Broadband. This project will strengthen a long-term alliance between researchers at the University of Melbourne and NEC Australia, one of the few multinational research laboratories with significant R & D presence in Australia. Researchers at the University of Melbourne with expertise in communication theory fundamentals will collaborate with experienced research and design engineers at NEC, to produce fundamental research, and the resulting design tools and intellectual property that will provide a new direction for wireless broadband access. The project will provide high-quality postgraduate and postdoctoral training in an area of great relevance to the Australian telecommunications industry.Read moreRead less
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
A high throughput Grid based environment for real time bio-medical imaging. Together with Leica, we will build a virtual microscope facility that will provide substantial functionality not currently available in Australia. This facility will have major national and international impact on bio-medical imaging. The software solutions and infrastructure, developed as part of this program will have considerable commercial and strategic value in their own right. One guaranteed avenue for exploitation ....A high throughput Grid based environment for real time bio-medical imaging. Together with Leica, we will build a virtual microscope facility that will provide substantial functionality not currently available in Australia. This facility will have major national and international impact on bio-medical imaging. The software solutions and infrastructure, developed as part of this program will have considerable commercial and strategic value in their own right. One guaranteed avenue for exploitation of the software will clearly be through our industry partner, Leica. Importantly, our proposal consolidates a critical mass of expertise connecting biomedical with computer science, thereby addressing a well-recognised constraint that to date has limited their national and international impact.Read moreRead less
Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early ....Discovery of Novel Respiratory Viruses Causing Influenza-Like Illness in Healthy Australian Adults Aged 18 to 64 Years. This work will inform our understanding of the causes of acute respiratory illnesses in Australia at the present time by looking for both known and previously undiscovered respiratory viruses. Increasing the knowledge base regarding causes of disease will have downstream relevance for health policy planners seeking to assess the burden of disease due to different causes. Early identification and description of new diseases will allow pre-emptive evaluation of new public health threats. This information will help to ensure availability and marketability of vaccines to prevent infection.Read moreRead less
Advanced coding techniques for next generation NAND Flash memories. Advanced coding techniques for next generation NAND Flash memories. This project aims to design low-power consuming coding schemes that can achieve the maximum coding gain for NAND Flash memories in Solid State Drives. Although these devices are replacing hard drives in laptops and provide enormous benefits in access speed and weight, they become unreliable the more they are used. Advanced coding techniques are needed to solve p ....Advanced coding techniques for next generation NAND Flash memories. Advanced coding techniques for next generation NAND Flash memories. This project aims to design low-power consuming coding schemes that can achieve the maximum coding gain for NAND Flash memories in Solid State Drives. Although these devices are replacing hard drives in laptops and provide enormous benefits in access speed and weight, they become unreliable the more they are used. Advanced coding techniques are needed to solve problems caused by the very strict reliability/cost requirements of large storage systems. Allocating memory to coding redundant information can extend these devices’ lifetime. The design of codes and decoders with a low power consumption is expected to be the key enabling technology for next generation large storage devices.Read moreRead less
DEEP DRILLING OF THE HUMAN PLASMA PROTEOME. Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers ....DEEP DRILLING OF THE HUMAN PLASMA PROTEOME. Like turning out city lights lets you see the faint stars more clearly - removal of high abundance proteins from human biofluids allows quantum leaps in biomarker discovery. This project will develop products that remove the biggest obstacle in proteomics - high abundance proteins (city lights). Cheap, efficient and routine removal of abundant proteins will amplify the power of ?cutting edge? proteomic technologies in the discovery of novel biomarkers. This is possible because undiscovered low copy number biomarkers (faint stars) exist in human diagnostic fluids at levels far lower than current proteomic array detection limits.Read moreRead less
Novel Self Assembled Particle Systems as a Key to Next Generation Biosensor Technology. Development and commercialisation of products utilising nanotechnology is crucial to future wealth creation for Australia. The translational research in this proposal will progress innovative concepts in nanotechnology-based biosensors, with potential for substantial improvements in disease diagnosis, leading to more economical and timely therapy. The products that arise from this research will also provide f ....Novel Self Assembled Particle Systems as a Key to Next Generation Biosensor Technology. Development and commercialisation of products utilising nanotechnology is crucial to future wealth creation for Australia. The translational research in this proposal will progress innovative concepts in nanotechnology-based biosensors, with potential for substantial improvements in disease diagnosis, leading to more economical and timely therapy. The products that arise from this research will also provide further employment for Australians, building on Universal Biosensor’s proven record of commercialization in Australia. The project will lead to training of Australian researchers in nanotechnology and in utilization of key Australian science infrastructure including the Australian Synchrotron and the Melbourne Centre for Nanofabrication.Read moreRead less
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less