Reconciliation strategies for continuous variable quantum key distribution. This project aims to advance a novel key distribution method, called quantum key distribution, which distributes secure keys using the quantum state of optical channels. Key distribution is a foundational part of data security, allowing digital keys to be securely exchanged between two or more parties, before they are used to protect and share information. The expected outcome is new rateless error correction codes desi ....Reconciliation strategies for continuous variable quantum key distribution. This project aims to advance a novel key distribution method, called quantum key distribution, which distributes secure keys using the quantum state of optical channels. Key distribution is a foundational part of data security, allowing digital keys to be securely exchanged between two or more parties, before they are used to protect and share information. The expected outcome is new rateless error correction codes designed specifically to implement quantum key distribution over long distances. Quantum key distribution is beneficial for ultra-secure communications as it avoids the vulnerability to weak random numbers and quantum-computing brute force attacks that currently threated the security of data protected by existing methods. Read moreRead less
Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automate ....Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automated classification and de-obfuscation technologies are a precondition to applying more sophisticated detection heuristics. The project will be instrumental in safeguarding Australia by protecting critical infrastructure and defending us from online organised crime and information warfare.Read moreRead less
Satellite Data Communications for Remote Sensing and Broadband Connectivity. The remote, distributed location of many of Australia's primary industries preclude the use of consumer-oriented terrestrial wireless broadband services. In many instances, satellite communications provides the only feasible means of connectivity for telemetry, supervisory control and data acquisition, tracking and fleet management. Meteorology, remote sensing, irrigation, mining, oil and gas exploration, and fisheries ....Satellite Data Communications for Remote Sensing and Broadband Connectivity. The remote, distributed location of many of Australia's primary industries preclude the use of consumer-oriented terrestrial wireless broadband services. In many instances, satellite communications provides the only feasible means of connectivity for telemetry, supervisory control and data acquisition, tracking and fleet management. Meteorology, remote sensing, irrigation, mining, oil and gas exploration, and fisheries are just a few examples of high-value applications of particular significance to Australia. This project will develop bandwidth efficient satellite communications technologies that greatly reduce cost and pave the way toward new market opportunities for broadband access and telemetry applications. Read moreRead less
Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics ....Gene Expression Profiling and de novo Transcriptome Sequencing using Geneballs. The purpose of the project is to demonstrate that bead-based technology can be used in applications that currently require DNA hybridisation in order to overcome existing deficiencies in microarray technology. By providing the capability to quickly and efficiently produce, screen and utilize biomolecule libraries of nearly unlimited size, this technology provides the key to unlock the power of genomics and proteomics for use in real world applications. The project has two aspects. First, relatively small directed cDNA-bead libraries will be compared to known low-density cDNA microarrays to validate the technique for utility in gene expression profiling. Secondly, large libraries containing short oligonucleotide sequences will be used for de novo sequencing of a complete transcriptome. Proof-of-concept in either case will pave the way for many genomic applications and catapult the technology to 'blockbuster' status.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Cooperative Mesh Networks for Municipal Wireless Access. Robust mobile broadband data communication is vital for public safety and emergency services applications. This project will improve the performance and cost-effectiveness of mesh networks, enabling new network architectures. Immediate benefits to Australia will be: Contribution to a growing knowledge base and fundamental capabilities wireless broadband communications; Education of future leading academic and industrial innovators; Raising ....Cooperative Mesh Networks for Municipal Wireless Access. Robust mobile broadband data communication is vital for public safety and emergency services applications. This project will improve the performance and cost-effectiveness of mesh networks, enabling new network architectures. Immediate benefits to Australia will be: Contribution to a growing knowledge base and fundamental capabilities wireless broadband communications; Education of future leading academic and industrial innovators; Raising the international profile of Australian research in information technology. The contribution of Information and Communications Technology to the National economy is widely recognized. ICT contributes to wealth creation, employment and exports, underpinning many innovation processes.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this count ....Development and commercialization of novel diagnostic assays for the early detection of acute dengue virus infection. Dengue is an emerging disease of the tropics and is endemic in more than 100 countries with up to 100 million cases annually. Of these, 500,000 result in dengue haemorrhagic fever (DHF), a serious life-threatening complication of dengue virus infection. Dengue activity in northern Australia has increased in recent years with suggestions that it may be coming endemic in this country. Early diagnosis, using NS1 based assays should facilitate containment of such outbreaks through earlier identification, treatment, isolation and strategic mosquito control.Read moreRead less
Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of rese ....Establishment of Therapeutically Relevant Animal Models and Markers for Crohn's Disease. Crohn's disease is a devastating life long disease, affecting 0.5% of the world population. There is urgent economic and social need to develop new and better drugs to treat the symptoms and underlying cause of this debilitating disease. Social benefits include the improved quality of life of sufferers that positively impacts society. Economic benefit includes income derived from commercialisation of research outcomes and the contribution this project makes to high value employment in the biotechnology sector.Read moreRead less