Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
Closing the Gap: Fundamental Capacity Limits for Interfering Wireless Networks and Practical Methods to Get There. Enhancing communication networks to achieve broadband data rates is now a national priority. Wireless communications is hugely important, with mobile phones, wireless computers, and wireless Internet access to homes, all rapidly growing areas. This project addresses the fundamental bottleneck of interference between links in wireless networks. Wireless unplugs the user and allows hi ....Closing the Gap: Fundamental Capacity Limits for Interfering Wireless Networks and Practical Methods to Get There. Enhancing communication networks to achieve broadband data rates is now a national priority. Wireless communications is hugely important, with mobile phones, wireless computers, and wireless Internet access to homes, all rapidly growing areas. This project addresses the fundamental bottleneck of interference between links in wireless networks. Wireless unplugs the user and allows him/her to roam, and to set up ad-hoc networks with other users. This research will thus contribute to Australia's increased productivity. Just as importantly, this project addresses fundamental research; it will increase Australia's knowledge base and provide training for students and researchers in how to think about communications problems.Read moreRead less
Information Capacity of High Data Rate Wireless Networks. Future wireless networks must support huge data rates in order to meet
the escalating demands of emerging Internet applications. Required
capacities far exceed those which can be provided by existing wireless
systems. Space-time coding is one very promising new technique which
may provide a solution. In spite of the potentials of this technique,
there are many important practical issues that affect the realizable
capacities. We a ....Information Capacity of High Data Rate Wireless Networks. Future wireless networks must support huge data rates in order to meet
the escalating demands of emerging Internet applications. Required
capacities far exceed those which can be provided by existing wireless
systems. Space-time coding is one very promising new technique which
may provide a solution. In spite of the potentials of this technique,
there are many important practical issues that affect the realizable
capacities. We aim to investigate two such issues: the impact of
channel uncertainty at the receiver, and the impact of multiple access
interference. This research will provide new directions for the design
of wireless data networks.
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Index coding for multimedia content distribution networks. The project aims to develop new bandwidth-efficient index coding schemes to reduce network congestion. A large portion of the increasing internet traffic is due to video content browsing and distribution. This creates serious strains on the current network infrastructure, which is designed to support conventional data. It is crucial to explore new avenues to reduce the network congestion due to large file downloads. The project aims to t ....Index coding for multimedia content distribution networks. The project aims to develop new bandwidth-efficient index coding schemes to reduce network congestion. A large portion of the increasing internet traffic is due to video content browsing and distribution. This creates serious strains on the current network infrastructure, which is designed to support conventional data. It is crucial to explore new avenues to reduce the network congestion due to large file downloads. The project aims to tackle this problem by exploring new index coding techniques that are robust to failures in wireless and wired network links. Using advanced mathematical tools from algebraic number theory and module theory, the project aims to design optimally bandwidth-efficient index coding schemes that enable timely and reliable content distribution to end users.Read moreRead less
Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automate ....Analysis and classification of malicious code. Malicious software such as viruses and worms directly attacks the security, privacy and integrity of Australian e-commerce, large databases and communication channels. The recent uptake of malicious software by organised crime has made finding effective countermeasures more urgent. Around 80% of the malicious code in circulation is disguised in some way. This significantly increases the difficulty of automated detection and delays analysis. Automated classification and de-obfuscation technologies are a precondition to applying more sophisticated detection heuristics. The project will be instrumental in safeguarding Australia by protecting critical infrastructure and defending us from online organised crime and information warfare.Read moreRead less
Smart coding for improved performance of complexity constrained devices. The technical innovations of this project have the potential to have an immediate impact on compression technology. The overall expected outcome of the project consists of new compression algorithms for the australian telecommunications industry. The novel outcomes of the project lead to better quality images in video mobile communications applications. As such, the project operates at the forefront of innovative next gener ....Smart coding for improved performance of complexity constrained devices. The technical innovations of this project have the potential to have an immediate impact on compression technology. The overall expected outcome of the project consists of new compression algorithms for the australian telecommunications industry. The novel outcomes of the project lead to better quality images in video mobile communications applications. As such, the project operates at the forefront of innovative next generation mobile video telephony.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Advanced nanoparticle stabilisation and functionalisation: small particles with huge potential. Australia is strongly investing in nanotechnology and through the governments priority goals 'Frontier Technologies for Building and Transforming Australian Industries' it has been recognised as an important area for investment. This proposal will help develop an internationally recognised nano-industry. It is envisaged that the particles made during this work will have direct implications for the pub ....Advanced nanoparticle stabilisation and functionalisation: small particles with huge potential. Australia is strongly investing in nanotechnology and through the governments priority goals 'Frontier Technologies for Building and Transforming Australian Industries' it has been recognised as an important area for investment. This proposal will help develop an internationally recognised nano-industry. It is envisaged that the particles made during this work will have direct implications for the public - creating a new class of medical diagnostic particles with better resolution and specificity. These particles have the potential to diagnose patients more precisely and at an earlier stage than is currently available. Additionally, these particles could be designed to load drugs and hence could be used to treat diseases such as cancer.Read moreRead less
Information theoretic approaches to optimise genome wide association studies with application to continuous and discrete traits. This project aims to develop new mathematical methods to find genetic associations from new genome-wide studies of colorectal cancer and breast cancer risk factors. If successful, this will result in improved use of expensive genetic data to better predict and understand diseases, conditions and other characteristics for humans, animals and plants.
Efficient and effective algorithms for searching strings in secondary storage. Pattern searching is fundamental to a wide range of computing applications, including web search and bioinformatics. In this project we will develop compression algorithms and hybrid memory-disk search structures that allow fast pattern matching on sequences of textual and numeric data, including when approximate search is required.