Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100219
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
A multi-institutional environmental radioactivity research centre. This project aims to establish an environmental radioactivity research centre, equipped with ultra-low background and high-resolution alpha and gamma spectrometry systems, radon detectors and radium delayed coincidence counters. The centre will address a critical demand in Australia for precise analysis of a large suite of natural and artificial radionuclides, which will be used as tracers and chronological tools to investigate k ....A multi-institutional environmental radioactivity research centre. This project aims to establish an environmental radioactivity research centre, equipped with ultra-low background and high-resolution alpha and gamma spectrometry systems, radon detectors and radium delayed coincidence counters. The centre will address a critical demand in Australia for precise analysis of a large suite of natural and artificial radionuclides, which will be used as tracers and chronological tools to investigate key questions in oceanography and the mining and energy, archaeological, agricultural, and forestry sectors. The facility is expected to substantially increase expertise and training in radionuclides in Australia, and promote high-level research collaborations and outputs of both national and international significance. Major outcomes of the proposed facility include better understanding of how oceans regulate climate and improved capacity to assess effects of radiation on natural ecosystems.Read moreRead less
The identification, prevention and management of chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises a number of research methods to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being ....Surviving the data deluge: Scalable feature extraction, discrimination and analysis for computer vision tasks using compressed sensed data. Strategically, our pioneering solutions besides being technically and socially significant, open fresh options for sensor-agnostic data analysis. The technical significance lies through the creation of new technologies for the critical national and global security markets, currently overwhelmed by data. The social significance arises from our solutions being privacy preserving, providing new avenues for the production of novel, socially acceptable products for aged care monitoring. Our methods spearhead future advancement in diverse disciplines due to the wide applicability of the methods to other sensor networks (Square Kilometre Array) and data types, providing new frameworks for addressing crucial problems of data management. Read moreRead less
Performance of waste stabilisation ponds: controlling factors, novel performance indicators, and risk assessment. As the world population increases, maintaining robust, cost-effective and environmentally safe wastewater treatment systems is of vital importance. This project will enhance the ability to design, operate and manage Australia's extensive wastewater infrastructure for safer and more sustainable water resources in Australia and the world.
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaire ....Diagnosing river health using invertebrate traits and DNA barcodes. Diagnosing river health using invertebrate traits and DNA barcodes. This project aims to develop indices that link change in invertebrate communities to specific environmental stressors, and combine these indices with innovative, low cost molecular approaches to species identification to rapidly identify the causes of decline. River health assessment methods, usually based on aquatic invertebrates, identify if rivers are impaired but must be developed to identify the causes of decline. The intended outcomes are improved sustainable water resource management within and among states, and improved natural resource policy development.Read moreRead less
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100049
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arriv ....Establishment of the Australian data archive: an integrated research facility for the social sciences and humanities. The Australian data archive will enable Australia's leading researchers to address complex social, economic and environmental problems, leading to the development of evidence based policy. The archive will have an open access policy which will ensure that the general public, media and government and non-government agencies are able to examine the data used by researchers to arrive at their conclusions.Read moreRead less
One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to l ....One of the current challenges in public health is to translate the progress from the Human Genome Project into reduced morbidity and mortality from disease. Once genetic defects are characterised, knowledge about the variability in severity of disease in mutation carriers, is important from a public health perspective. Hereditary Haemochromatosis (HH) is a common genetic disorder of iron overload that results in a wide spectrum of disease, varying from non-specific symptoms to severe damage to liver, heart, pancreas and joints from iron deposition. It is easily treatable by regular blood donation, and population-based screening for HH has therefore been advocated. In this study we aim to address gaps in the existing data on HH regarding dietary and lifestyle factors that contribute to the variable clinical picture of HH. The study will be based on the Melbourne Collaborative Cohort Study, a cohort of 31,500 men and women who have been followed for approximately 10 years. Information on dietary and lifestyle factors was collected at initial enrollment, along with a blood specimen. We will test all non-Southern European participants (31,176) for the common HH mutations in the HFE gene and then select a subgroup of 1150 people, including all people with the main genetic defect as well as a comparison group, for further clinical followup. Participants will have genetic counselling and informed consent will be obtained. Participants will complete a short questionnaire and give a blood sample for measurement of iron overload, liver function, and other relevant blood tests, then undergo a brief clinical examination. Results of all tests will be given at a followup visit by genetic counsellor or physician. This study will provide important data on natural history of HH risk factors that influence variability in clinical presentation and the association of HFE mutations with chronic diseases and all cause mortality.Read moreRead less