Reducing Colorectal Cancer Burden In Young Adults: Precision Prevention And Early Detection
Funder
National Health and Medical Research Council
Funding Amount
$1,449,800.00
Summary
Bowel cancer rate in young adults before age 50 is increasing worldwide including Australia. Since it is impossible to screen everyone, it is critical to identify who is likely to develop the disease, to optimise screening. Using the world's largest resource for young-onset bowel cancer, I will conduct studies to generate high-quality evidence to inform how to best prevent bowel cancer in young adults and translate into the policy and practice, to reduce colorectal cancer burden in young adults.
Discovery Early Career Researcher Award - Grant ID: DE240100040
Funder
Australian Research Council
Funding Amount
$442,302.00
Summary
Quality Assurance of Mobile Applications by Effective Testing and Repair. This project aims to create advanced techniques that will enable software engineers to effectively develop quality assured and robust software systems. This project expects to generate new and innovative approaches that automate software testing and repair. The expected outcomes of this project include new knowledge of software engineering, development of an automated and cost-effective testing system with improved coverag ....Quality Assurance of Mobile Applications by Effective Testing and Repair. This project aims to create advanced techniques that will enable software engineers to effectively develop quality assured and robust software systems. This project expects to generate new and innovative approaches that automate software testing and repair. The expected outcomes of this project include new knowledge of software engineering, development of an automated and cost-effective testing system with improved coverage, greater bug detection and repair, and faster testing protocols. This should provide significant benefits to software users by providing reliable and user-friendly systems and to software companies to position Australia as a global leader in software development and technological advancement.Read moreRead less
Develop A Strong Current Warning System And Inform Knowledge Of The Nearshore Current Regime Influencing The Western Rock Lobster Fishery
Funder
Fisheries Research and Development Corporation
Funding Amount
$199,000.00
Summary
By combining this greater coverage with information derived from commercial fishers (e.g. days when gear is drowned or lost to determine key current velocities) a purpose built webapp can be developed, hosted on an existing service, which allows fishers to asses the risks posed by ocean currents to their fishing operation before they set their gear. This would also allow for fishers to predict days when drowned gear may resurface and therefore the fishing operation may continue.
In addi ....By combining this greater coverage with information derived from commercial fishers (e.g. days when gear is drowned or lost to determine key current velocities) a purpose built webapp can be developed, hosted on an existing service, which allows fishers to asses the risks posed by ocean currents to their fishing operation before they set their gear. This would also allow for fishers to predict days when drowned gear may resurface and therefore the fishing operation may continue.
In addition to this helping the fishing operation, greater current modelling coverage over this part of the fishery will allow for the fine-scale assessment of the links between water movement and puerulus settlement. As part of FRDC project “2016-260 WRL IPA: assess causes and implications of anomalous low lobster catch rates in the shallow water areas near the centre of the Western Rock Lobster fishery” 40 additional puerulus collectors will be added to the current DOF monitoring program which will provide extensive coverage of settlement rates between Seven Mile, Dongara and Jurien Bay.
Objectives: 1. Establish additional coastal radar station 2. Establish a predictive warning system for ocean conditions that can be used by the WRL fishery to improve efficiency 3. Assess the relationship between water circulation and puerulus settlement rates Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100473
Funder
Australian Research Council
Funding Amount
$410,154.00
Summary
Effective integration of human and automated analyses for security testing. This DECRA project aims to significantly improve the performance of current state-of-the-art automated security testing approaches, enabling them to discover more security bugs in strict time constraints. The key innovation of the project is its novel way to embrace human element to leverage the ingenuity of the developers. This project will help companies improve the security and reliability of their products, thwarting ....Effective integration of human and automated analyses for security testing. This DECRA project aims to significantly improve the performance of current state-of-the-art automated security testing approaches, enabling them to discover more security bugs in strict time constraints. The key innovation of the project is its novel way to embrace human element to leverage the ingenuity of the developers. This project will help companies improve the security and reliability of their products, thwarting cyberattacks that cost Australian business $29 billion each year. The knowledge from this project will be transferred and integrated into higher education subjects to train the next generations of software developers, who are responsible to build security-critical systems that we all rely on now and in the future.Read moreRead less
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
The Detection Of Ciguatera Toxins In NSW Spanish Mackerel
Funder
Fisheries Research and Development Corporation
Funding Amount
$490,000.00
Summary
Ciguatera Fish Poisoning (CFP) causes the largest number of seafood-related food safety incidents in Australia. In NSW and southern QLD waters, CFP is mostly related to Spanish Mackerel (Scomberomorus commerson). Ciguatoxins (CTXs) produced by marine microalgae (Gambierdiscus spp), are polyether toxins that accumulate in fish and cause CFP when fish are eaten. CTXs are heat stable, odourless, tasteless, and toxic at low concentrations, therefore it is very difficult to distinguish toxic fish. In ....Ciguatera Fish Poisoning (CFP) causes the largest number of seafood-related food safety incidents in Australia. In NSW and southern QLD waters, CFP is mostly related to Spanish Mackerel (Scomberomorus commerson). Ciguatoxins (CTXs) produced by marine microalgae (Gambierdiscus spp), are polyether toxins that accumulate in fish and cause CFP when fish are eaten. CTXs are heat stable, odourless, tasteless, and toxic at low concentrations, therefore it is very difficult to distinguish toxic fish. In NSW, since 2014, 31 people have contracted CFP after consuming Spanish Mackerel caught locally, mostly through recreational fishing.
Validated commercial monitoring methods for CTXs are unavailable internationally, although research tools for CTX measurement have been developed. Regulatory methods for CFP prevention are to avoid certain fish species, fish of certain sizes (ie >10kg), or fish from certain regions. In Australia, effective prevention methods have not been clearly evaluated. This results in Spanish Mackerel that are safe to eat potentially being excluded from sale, resulting in significant losses (ie > ~$200k p.a in NSW). This project addresses this issue, which was identified as high priority in the Australian ciguatera research strategy formulated at a recent workshop (27-28th March, 2019).
In 2014, FRDC (Tactical Response) and the NSW Recreational Fisheries Trust funded an initial study on the incidence of CTXs in NSW Spanish Mackerel. CTX was present in flesh and liver samples (1-7% incidence), and was not clearly correlated with the weight of individual fish. This information showed that CFP risk management may require reassessment. This project will advance knowledge by: evaluating methods of detection of CTXs; determining detailed predictive data on CTX incidence; and evaluating environmental and biological factors associated with CTX in Spanish Mackerel to allow for an evaluation of risk assessment strategies. This information will benefit industry by enhancing consumer safety and industry confidence, and enabling the sale of safe Spanish Mackerel.
Objectives: 1. Determine industry CTX needs and conduct of review of available CTX measurement tools (including cell based assays, ELISA kits, and LCMS) against these needs. Conduct an assessment of the currently available screening tools to determine which, if any, hold promise for industry use. Conduct a viability assessment for how a tool might be used in industry or, if none of the currently available tools are appropriate, make recommendations for future activities to develop a rapid screening tool that meets industry needs. 2. Obtain samples of flesh and liver from ~300 individual Spanish Mackerel of all sizes caught in Industry relevant regions of NSW waters over a period of 2 years, as well as length, weight, sex and site information, with the participation of the Sydney Fish Market and commercial fishing Cooperatives. Obtain samples from any individual Spanish Mackerel associated with illnesses in NSW or QLD. Measure CTX1B and other available CTX analogs using best practice methods identified in Objective 1. 3. Conduct statistical data analyses of all available data on CTX concentrations in Spanish Mackerel in comparison to biological and environmental variables.Develop recommended options for food safety risk management for Spanish Mackerel in NSW that will allow for a viable industry while protecting public health. Read moreRead less
Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at enviro ....Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at environmentally regulated levels. This will provide a single platform for at-site near-real-time monitoring of water chemistry for agricultural, mining, water corporations and other industries that use and/or discharge water to the environment. Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100441
Funder
Australian Research Council
Funding Amount
$474,443.00
Summary
Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of ani ....Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of animal sounds and communities to generate metrics that are informed by animal ecology and directly address monitoring needs of conservation organisations. By experimentally testing the metrics on long-duration real-world sound data, this project will provide new tools to measure conservation impact and prioritise actions.Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In ....eGenomics - Next generation biomonitoring of threatened species. DNA is the molecule of life and exists everywhere in the environment as a largely untapped source of information on evolution, biodiversity, and ecosystem health. Our overriding aim is to start mining that information to benefit threatened species. Based on optimized ancient DNA methods, powerful sequencing technology, whole genome analyses, and RNA profiling, we present a novel and holistic framework for genetic biomonitoring. In two parallel model systems we will study corals and reptiles to improve environmental detection while simultaneously obtaining information on their population health. This will foster more efficient conservation of endangered species that are of tremendous importance to our marine and terrestrial ecosystems.Read moreRead less