Structural Characterisation Of The Co-inhibitory Complex Formed By The Tumour Suppressor PTEN And The Metastatic Factor PREX2
Funder
National Health and Medical Research Council
Funding Amount
$563,602.00
Summary
Metastasis is a major cause of cancer mortality. Characterisation of key proteins that regulate metastasis is therefore a priority. PTEN and PREX2 are enzymes that play key roles in metastasis in melanoma, and other cancers. We will determine the structural basis of PTEN:PREX2 co-inhibition, and determine how cancer-associated PREX2 mutations dysregulate this inhibitory complex. This study will provide the necessary knowledge for future drug development programs targeting PTEN:PREX2 in cancer.
Structural And Functional Characterisation Of The Oncogene P-Rex1
Funder
National Health and Medical Research Council
Funding Amount
$623,447.00
Summary
The spread of cancer to other parts of the body (metastasis) is a major cause of mortality. The characterisation of proteins that regulate metastasis is therefore a priority. P-Rex1 plays a crucial role in promoting metastasis in breast and other cancers. We will determine the structural basis of P-Rex1 activity, and investigate how its dysregulation promotes aberrant cell growth. This study will provide the knowledge to build future drug development programs targeting P-Rex1 in cancer.
Targeting NDM-producing ‘superbugs’: Optimising Novel Combinations With ‘old’ Polymyxins Using Pharmacological, Molecular Imaging And Systems Biology Approaches
Funder
National Health and Medical Research Council
Funding Amount
$582,732.00
Summary
Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these ver ....Rapid global spread of so-called NDM-producing bacterial ‘superbugs’ is presenting a major medical challenge. Without new antibiotics under development, polymyxin is becoming the only effective antibiotic. Unfortunately we recently revealed that treatment with polymyxin alone can rapidly lead to resistance in NDM-producing ‘superbugs’. This project will employ new tools to optimise rational polymyxin combinations, thereby providing urgently needed information to clinicians for treating these very problematic infections.Read moreRead less
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Structural Events In Insulin And IGF Signalling - A Nanodisc Approach To A Problem In Cancer, Diabetes And Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$752,403.00
Summary
Insulin and its insulin-like growth factors play a major role in three major disease states facing ageing Australians—diabetes, cancer and Alzheimer's disease. We aim to understand how these proteins send messages into cells via their so-called receptors. We will isolate the receptor molecules from cells and then image them in an advanced electron microscope to produce three-dimensional images. Our findings will have implications for the design of therapeutics targeting the above three diseases.
Discovery Early Career Researcher Award - Grant ID: DE150100288
Funder
Australian Research Council
Funding Amount
$348,000.00
Summary
Geoblocking, circumvention and the organisation of digital media markets. Digital content portals including iTunes, Hulu, Netflix and BBC iPlayer use geoblocking to restrict access in certain markets. Australian consumers are increasingly finding ways to circumvent such restrictions. This project aims to investigate how geoblocking and geoblocking circumvention are shaping digital media consumption in Australia. It will offer rigorous analysis of an emerging transnational media practice, and wha ....Geoblocking, circumvention and the organisation of digital media markets. Digital content portals including iTunes, Hulu, Netflix and BBC iPlayer use geoblocking to restrict access in certain markets. Australian consumers are increasingly finding ways to circumvent such restrictions. This project aims to investigate how geoblocking and geoblocking circumvention are shaping digital media consumption in Australia. It will offer rigorous analysis of an emerging transnational media practice, and what it means for audiences, producers and regulators. This project endeavours to advance the understanding of digital content flows and inform media policy in a volatile regulatory environment.Read moreRead less
Investigating Cytoskeletal Dynamics Across The Lifecycle Of The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$387,741.00
Summary
During its lifecycle the malaria parasite must cross tissues and invade cells in two very different hosts - humans and mosquitos. Although the molecules that drive this process are known, we know nothing about their dynamics in live parasites. Here, we will use state-of-the art microscopy and genetics to dissect parasite motility, tracking proteins in the parasite cell on their journey from human host through to the mosquito - utilising the first Australian malaria-dedicated insectary.
Next generation front projection screens. Consumer electronics is a huge international market and home theatre is one of the most rapidly growing sectors. A critical part of the home theatre system is the projection screen, an area of technology that has seen only incremental development over the last fifty years, or so. In this project we will take some advanced design concepts developed at the University of Melbourne for laser technology and adapt them to the development of novel approaches to ....Next generation front projection screens. Consumer electronics is a huge international market and home theatre is one of the most rapidly growing sectors. A critical part of the home theatre system is the projection screen, an area of technology that has seen only incremental development over the last fifty years, or so. In this project we will take some advanced design concepts developed at the University of Melbourne for laser technology and adapt them to the development of novel approaches to improving the brightness and resolution of projection screens. The project will look at the design process and address the manufacturing challenges for novel projection screen technology.Read moreRead less
Internet-distributed television: cultural, industrial and policy dynamics. This project aims to investigate the impact of global subscription video-on-demand platforms on national television markets. The rise of subscription video streaming has created significant challenges for Australian and international broadcast, media and cultural policy frameworks, which are struggling to keep up with audience viewing practices. This project will provide a comparative analysis of how governments are respo ....Internet-distributed television: cultural, industrial and policy dynamics. This project aims to investigate the impact of global subscription video-on-demand platforms on national television markets. The rise of subscription video streaming has created significant challenges for Australian and international broadcast, media and cultural policy frameworks, which are struggling to keep up with audience viewing practices. This project will provide a comparative analysis of how governments are responding and investigating the implications for debates about local content, local screen production, and media diversity. The project will provide an analysis of original production and programming strategies to identify new forms of trans-national media flow. The project will advance an understanding of media globalisation and provide media regulators options and opportunities for a convergent media policy environment.Read moreRead less
Artistic Practice in Australian Videogame Development. The game industry is the largest cultural industry in the world. Its economic growth relies in part on the artistic innovations of non-commercial developers and communities operating beyond the industry’s purview. Policymakers and researchers alike struggle to account for the cultural contexts and creative origins of game development. This project conceptualises and empirically investigates ‘artist-gamemaking’ to generate new knowledge on th ....Artistic Practice in Australian Videogame Development. The game industry is the largest cultural industry in the world. Its economic growth relies in part on the artistic innovations of non-commercial developers and communities operating beyond the industry’s purview. Policymakers and researchers alike struggle to account for the cultural contexts and creative origins of game development. This project conceptualises and empirically investigates ‘artist-gamemaking’ to generate new knowledge on the ambitions, techniques and histories of Australia’s game industry. It develops resources that will enable cultural institutions to better support them. This research is important as it articulates the cultural and economic value of a vital site of creative practice in contemporary Australia.Read moreRead less