The Role Of Microtubule Composition In The Efficacy Of Antimicrotubule Agents In Paediatric Malignancy
Funder
National Health and Medical Research Council
Funding Amount
$173,380.00
Summary
To enhance the management of both childhood and adult cancers improved understanding of the processes responsible for tumour aggressiveness and drug resistance are required. Microtubules are important structural components of cells which are crucial for normal cell division. This makes microtubules excellent targets for anticancer drugs which can disrupt microtubules and kill cancer cells. This proposal will identify whether the microtubule composition of a tumour cell will predict for the aggre ....To enhance the management of both childhood and adult cancers improved understanding of the processes responsible for tumour aggressiveness and drug resistance are required. Microtubules are important structural components of cells which are crucial for normal cell division. This makes microtubules excellent targets for anticancer drugs which can disrupt microtubules and kill cancer cells. This proposal will identify whether the microtubule composition of a tumour cell will predict for the aggressiveness of certain cancers, and whether this influences which tumours will respond to the vinca alkaloids. The vinca alkaloids are an important class of natural product drugs which disrupt microtubules and are particularly effective in the treatment of adult and childhood cancers. Unfortunately, some cancer cells fail to respond to this treatment due to the development of drug resistance. This proposal addresses vinca alkaloid resistance in children?s cancer and will determine why certain cancer cells fail treatment. Furthermore, this study will identify the role of certain components of microtubules that appear to be related to drug resistance in leukaemia and neuroblastoma cells and whose role is unknown. Chemotherapeutic drugs, such as the vinca alkaloids, are important in the treatment of cancer and knowledge about their interaction with their cellular target will improve the design of new drugs and treatment outcome.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100055
Funder
Australian Research Council
Funding Amount
$451,415.00
Summary
Impact of seaweed polyphenols on gut health: Gut microbiome modulation. This project aims to understand the true impact of seaweed polyphenols on the gut microbiome and develop methods to improve their bioavailability, bioaccessibility and bioactivities in the gut. The project's use of cutting-edge analytical tools helps to investigate the movement and absorption of phenolic compounds across the gut. This project expects to explore new knowledge in the area of marine-based functional foods and t ....Impact of seaweed polyphenols on gut health: Gut microbiome modulation. This project aims to understand the true impact of seaweed polyphenols on the gut microbiome and develop methods to improve their bioavailability, bioaccessibility and bioactivities in the gut. The project's use of cutting-edge analytical tools helps to investigate the movement and absorption of phenolic compounds across the gut. This project expects to explore new knowledge in the area of marine-based functional foods and their health benefits using an innovative interdisciplinary approach. The success of this project will ultimately provide a new pathway for the development of functional foods that will help to improve the health status of Australians by consuming healthy food ingredients.Read moreRead less
Pilot-scale production of therapeutically-active cannabinoids . The Isolation of minor therapeutically-active cannabinoids from cannabis at pilot scale would establish a commercially competitive Australian industry and lead to a superior position in the global marketplace. This project aims to select elite clones from genetically diverse cannabis strains for yield of minor, but therapeutically-active, cannabinoids, and develop a pilot-scale extraction and separation procedure that can be scaled- ....Pilot-scale production of therapeutically-active cannabinoids . The Isolation of minor therapeutically-active cannabinoids from cannabis at pilot scale would establish a commercially competitive Australian industry and lead to a superior position in the global marketplace. This project aims to select elite clones from genetically diverse cannabis strains for yield of minor, but therapeutically-active, cannabinoids, and develop a pilot-scale extraction and separation procedure that can be scaled-up for commercial production. This would contribute to the growth of the agri-biotechnology sector and a skilled multidisciplinary workforce in rural Australia, thus providing significant economic benefit. The novel scale-up procedure has potential for industry adoption to add value to Australian manufacturing.
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Industrial Transformation Research Hubs - Grant ID: IH180100006
Funder
Australian Research Council
Funding Amount
$4,995,391.00
Summary
ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation ....ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation of novel lead compounds. This knowledge will be applicable across related industries and build the specialised workforce needed to underpin Australia’s developing medicinal agriculture industry.Read moreRead less