A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcom ....Yarning with our mob about human papillomavirus (HPV) vaccination uptake. This project aims to identify a range of modifiable factors that affect the participation of Indigenous adolescents in human papillomavirus (HPV) vaccination school programs. The project expects to generate new knowledge by combining Indigenous methodologies and a socioecological model to explore policy, community, interpersonal and intrapersonal factors impacting HPV vaccination uptake for this population. Expected outcomes include a more comprehensive understanding of the factors behind the low rates of HPV vaccination among Indigenous adolescents. This information should provide significant benefits including the identification of modifiable factors to increase HPV vaccination rates for Indigenous adolescents.Read moreRead less
Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and u ....Co-designing a Food Sovereignty Model with Indigenous Communities. Food sovereignty asserts the rights of people and communities to healthy and culturally appropriate foods through determination of their own food and agriculture systems. With food insecurity higher among Indigenous households; a food sovereignty approach offers the potential for sustainable long-term solutions that maintain human dignity and reinvigorate knowledge systems. Drawing on national and international perspectives and using Indigenous research methodologies, this project aims to co-design a food sovereignty model that will enable Indigenous communities to effectively address food insecurity according to their local contexts. Both the process and solutions will contribute to improvements in physical, mental and social wellbeing.Read moreRead less
Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our e ....Historical frontier violence: drivers, legacy and the role of truth-telling. This project aims to build data to identify the historical factors that incited frontier violence; quantify the legacy on communities today and conduct fieldwork to understand how historical trauma is transmitted across generations. This project expects to develop new knowledge on the circumstances and legacy of settlement and the origins of gaps in life prospects between Indigenous and non-Indigenous Australians. Our expectation is that this will increase public acceptance of the circumstances of settlement and the need to make amends. This project should help increase public support for truth-telling and better relations between Indigenous and non-Indigenous Australians, a vital step towards reconciliation and healing the nation. Read moreRead less
Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-suppo ....Healing Country: integrating knowledge systems to meet climate challenges. Aboriginal and Torres Strait Islander communities are currently experiencing severe environmental challenges related to a changing climate. Led by Aboriginal communities, this project aims to integrate traditional knowledges and environmental and health data to create community story-data maps. These interactive, online maps will be a unique and powerful blend of information, providing a rich evidence base, decision-support and communication tool to inform the co-design of local climate change mitigation, adaptation and resilience plans. The project aims to give agency to Aboriginal communities in leading a systems change process to reduce environmental risks and strengthen health and wellbeing.Read moreRead less
Knowledge integration for Torres Strait sustainability. This project aims to investigate how Torres Strait Islanders use context-specific local knowledge and research evidence to address environmental sustainability challenges. The Torres Strait is experiencing significant threats to its environment and there is a need to use research to identify strategies that can meet these challenges. However, at present significiant barriers exist in the translation of current research knowledge to the Torr ....Knowledge integration for Torres Strait sustainability. This project aims to investigate how Torres Strait Islanders use context-specific local knowledge and research evidence to address environmental sustainability challenges. The Torres Strait is experiencing significant threats to its environment and there is a need to use research to identify strategies that can meet these challenges. However, at present significiant barriers exist in the translation of current research knowledge to the Torres Strait context. The project will examine how knowledge is constructed (culturally) and develop new methods to allow research findings to be integrated into Torres Strait knowledge. This project will support the empowerment of Torres Strait Islander people to seek the research information that is most useful for their decision-making.Read moreRead less
Vitality and change in Warlpiri songs at Yuendumu. Vitality and change in Warlpiri songs at Yuendumu. This project aims to understand the reasons behind the reported decline in knowledge of songs amongst younger generations at Yuendumu in the past 40-50 years, using a Central Australian music archive. This project will analyse selected song repertories over time, with insights and advice from today's senior custodians; and design strategies for Warlpiri people to re-engage with this important bo ....Vitality and change in Warlpiri songs at Yuendumu. Vitality and change in Warlpiri songs at Yuendumu. This project aims to understand the reasons behind the reported decline in knowledge of songs amongst younger generations at Yuendumu in the past 40-50 years, using a Central Australian music archive. This project will analyse selected song repertories over time, with insights and advice from today's senior custodians; and design strategies for Warlpiri people to re-engage with this important body of Warlpiri-initiated research in their own country. This research is expected to reinvigorate inter-generational transfer of highly significant cultural knowledge and practices.Read moreRead less
How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. This project aims to produce an authoritative and original interpretation of the Wild Australia Show (1892–93), staged by a diverse company of Aboriginal people for metropolitan audiences. The Show will be the focus of an interdisciplinary study of performance, photography, collections and race relations in colonial Australia, using archival and visual ....How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. How Meston's 'Wild Australia Show' shaped Australian Aboriginal history. This project aims to produce an authoritative and original interpretation of the Wild Australia Show (1892–93), staged by a diverse company of Aboriginal people for metropolitan audiences. The Show will be the focus of an interdisciplinary study of performance, photography, collections and race relations in colonial Australia, using archival and visual records. The project will situate the Show in local, national and transnational narratives informed by contemporary Indigenous perspectives. This research should illuminate Aboriginal agency in the ensemble, reconnect Aboriginal kin to performers, and chart changing concepts of race at a critical juncture in Australian history.Read moreRead less