I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Development of Multilayered Packaging Materials with Controlled Barrier Properties. The project aims to develop advanced new material for multilayered packaging with high oxygen and moisture barrier properties for cost effective packaging applications. Poly Products currently imports and uses some polymer as its key component for controlling barrier property of their food packaging. However, the new nanostructured material when sandwiched between less expensive materials in a multilayered packag ....Development of Multilayered Packaging Materials with Controlled Barrier Properties. The project aims to develop advanced new material for multilayered packaging with high oxygen and moisture barrier properties for cost effective packaging applications. Poly Products currently imports and uses some polymer as its key component for controlling barrier property of their food packaging. However, the new nanostructured material when sandwiched between less expensive materials in a multilayered packaging film will yield excellent barrier properties, leading to extended shelf life of different food products. The new smart material will generate significant material saving and replace the imported polymer, and will secure export market of the product in Asia -Pacific region.Read moreRead less
Hepatitis C affects a quarter of a million Australians, causing insidious but progressive liver disease which culminates in liver failure or cancer. There is no vaccine and prevention programs have limited effectiveness, but new antiviral therapies now offer high rates of cure. This Program will evaluate strategies to improve the health of those affected and prevent new infections by better understanding of the virus and the body’s immune response, including scarring and liver cancer formation.
Interventions To Improve Outcomes For Young Aboriginal And Torres Strait Islander People In Sexually Transmissible Infections Blood Borne Viruses And For People Using Methamphetamines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This ECF will enable research to be carried out in the domains of sexually transmissible infections (STI) and blood borne viruses (BBV) and specifically methamphetamine (MA) use in Aboriginal communities nationally. Specific research outcomes will be the establishment of an Aboriginal primary health care and behavioural surveillance network for STIs/BBVs in nationally dispersed clinical hubs (CRE), and an improved understanding of interventions to address MA in Aboriginal communities.
Unusual trisulfide chemistry. This project aims to investigate the mechanism of an unexpected reaction of trisulfides with common amide-containing solvents. Specifically, these solvents (such as dimethylformamide) were discovered to cleave S-S bonds in trisulfides and related polysulfides. This project expects to generate new knowledge in the understanding of the reaction mechanism and then use that understanding for useful chemistry. Expected outcomes of this project include a mechanistic under ....Unusual trisulfide chemistry. This project aims to investigate the mechanism of an unexpected reaction of trisulfides with common amide-containing solvents. Specifically, these solvents (such as dimethylformamide) were discovered to cleave S-S bonds in trisulfides and related polysulfides. This project expects to generate new knowledge in the understanding of the reaction mechanism and then use that understanding for useful chemistry. Expected outcomes of this project include a mechanistic understanding of a new reaction, and the use of this chemistry in polymer synthesis and polymer recycling. This project should provide significant benefits in new knowledge, as well as support new strategies in polymer synthesis and recycling to benefit the environment.Read moreRead less
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.