Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Special Research Initiatives - Grant ID: SR0354584
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Multimedia Technology and Applications (MTA). Multimedia Information Technology is becoming a major stream for modern computers, networks, and new platforms (e.g. embedded-systems, mobile-phones, PDAs, digital-TV) in various applications, including media production and e-healthcare where Australia has tremendous strengths. This proposal aims to bring top researchers in the related areas, including IT, Healthcare, Architecture and Visual-arts, to push a new technological w ....ARC Research Network in Multimedia Technology and Applications (MTA). Multimedia Information Technology is becoming a major stream for modern computers, networks, and new platforms (e.g. embedded-systems, mobile-phones, PDAs, digital-TV) in various applications, including media production and e-healthcare where Australia has tremendous strengths. This proposal aims to bring top researchers in the related areas, including IT, Healthcare, Architecture and Visual-arts, to push a new technological wave in Australia, to provide its value promised to Australian business, and to take international leadership in multimedia computing. Its outcome includes the formation of research teams, coordinated by a board, for 10 programs, and a CSCW-system & related website to facilitate the group work.Read moreRead less
Identifying and controlling the source of Campylobacter and Salmonella in Australia. This project will identify the source of foodborne illnesses due to Salmonella and Campylobacter in order to inform food regulatory policy. The ultimate aim is to reduce the amount of foodborne disease in Australia.