Combating The Reemergence Of Tuberculosis With New Vaccine Strategies
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Tuberculosis is a major global public health problem with significant morbidity and mortality. This project aims to generate new, highly efficacious vaccination regimens against tuberculosis, especially pulmonary tuberculosis, which is the most difficult manifestation of the disease to control. The outcomes of this project have the potential to save millions of lives worldwide and to decrease socioeconomic burden of tuberculosis, particularly in the context of HIV co-infection.
Clinical And Genomic Aspects Of Staphylococcus Aureus And Other Infectious Diseases In Northern Australia.
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The burden of infectious disease is high in Indigenous populations in northern Australia and patterns of disease differ. My research proposes to deepen our understanding of infectious diseases such as that due to Staphylococcus aureus (golden staph), hepatitis B and influenza by applying cutting-edge technologies (e.g., bacterial genomics) to answer clinically relevant questions. Ultimately I hope to prevent transmission of infections, improve vaccine strategies and find better targets for treat ....The burden of infectious disease is high in Indigenous populations in northern Australia and patterns of disease differ. My research proposes to deepen our understanding of infectious diseases such as that due to Staphylococcus aureus (golden staph), hepatitis B and influenza by applying cutting-edge technologies (e.g., bacterial genomics) to answer clinically relevant questions. Ultimately I hope to prevent transmission of infections, improve vaccine strategies and find better targets for treatment.Read moreRead less
Impact Of Influenza A Infection On T Cell-mediated Immunity To Pulmonary Tuberculosis.
Funder
National Health and Medical Research Council
Funding Amount
$488,058.00
Summary
Tuberculosis is a leading cause of death worldwide and there is an urgent need to develop better anti-TB vaccines. Infection with respiratory viruses may reduce memory T cell responses to M. tuberculosis (Mtb). This project will investigate if Influenza A infection reduces memory anti-tuberculosis T cell responses in mice previously exposed to Mtb or BCG. We will then use influenza viruses engineered to carry parts of Mtb proteins to boost anti-Mtb T cell responses and the protective effect of B ....Tuberculosis is a leading cause of death worldwide and there is an urgent need to develop better anti-TB vaccines. Infection with respiratory viruses may reduce memory T cell responses to M. tuberculosis (Mtb). This project will investigate if Influenza A infection reduces memory anti-tuberculosis T cell responses in mice previously exposed to Mtb or BCG. We will then use influenza viruses engineered to carry parts of Mtb proteins to boost anti-Mtb T cell responses and the protective effect of BCG.Read moreRead less
Translating Bacterial Molecular Epidemiology Into Information To Improve Infectious Disease Risk Assessment And Control
Funder
National Health and Medical Research Council
Funding Amount
$494,500.00
Summary
Streptococcus pneumoniae (pneumococcus) and group B streptococcus (GBS) are important pathogenic bacteria, which cause septicaemia and meningitis in young infants, the elderly and people with certain chronic diseases. Both consist of a number of different types, some of which are more likely to cause disease than others. Pneumococcal vaccines that protect against the commonest pathogenic types are used in Australia in people most at risk.Antibiotic resistance is an increasing problem, which shou ....Streptococcus pneumoniae (pneumococcus) and group B streptococcus (GBS) are important pathogenic bacteria, which cause septicaemia and meningitis in young infants, the elderly and people with certain chronic diseases. Both consist of a number of different types, some of which are more likely to cause disease than others. Pneumococcal vaccines that protect against the commonest pathogenic types are used in Australia in people most at risk.Antibiotic resistance is an increasing problem, which should be partly off-set by immunisation. Giving antibiotics during labour, to women colonised with GBS, can reduce infection rates in newborns, but there are many disadvantages of this approach, including the risk of increased antibiotic resistance. Vaccines against GBS are mpt yet available. We have developed methods to identify detailed fingerprints of these bacteria which allow us to identify types, antibiotic resistance and, for GBS, other characteristics which can distinguish highly pathogenic strains from the majority that are carried harmlessly and unlikely to cause disease. The methods are still quite slow and expensive and produce complex patterns,which are difficult to interpret rapidly. We plan to develop a new, rapid and relatively inexpensive, fingerprinting system for these bacteria and computer programs to analyse and interpret the results. They will allow us to check the strains of pneumococci that cause disease to make sure that new ones, not covered by the vaccine, do not become more common and reduce the effectiveness of vaccine and that antibiotic resistance does not increase further. The methods will also allow us to study differences between the small proportion of GBS strains that cause neonatal infection and the majority that are carried harmlessly by pregnant women and are of little risk to their babies. Eventually this should allow doctors to identify women whose babies are most at risk, reduce unnecessary antibiotic use.Read moreRead less
Developing novel chemistries for removing environmental surface biofilms to reduce hospital acquired infections. This project will develop new detergents that more efficiently clean hospitals. This will increase hospital safety by decreasing infections, thus saving lives and healthcare costs.
Understanding heat shock protein complex vaccines. This project aims to understand the mechanism of action and formulation requirements of a novel vaccine technology that utilises heat shock protein complexes. By understanding how this technology works, future vaccines can be improved to induce the immune response required to target specific pathogens, as well as give assurance regarding its safety.
Identification Of Novel Gonococcal Virulence Factors And Vaccine Antigens Based On Their Expression During Host Cell Contact And Their Role In Association, Invasion And Survival In Cervical Epithelia
Funder
National Health and Medical Research Council
Funding Amount
$371,922.00
Summary
The sexually transmitted infection gonorrhoea is a significant health problem worldwide. Control of gonorrhoea depends on the development of a vaccine due to the continuing increase of antibiotic resistance and the staggering outcomes of infection, including infertility and increased transmission of HIV. My research aims to discover new vaccine targets by identifying gonococcal proteins that are required for interaction with human cervical cells.