AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Molecular & Neuropsychological Predictive Markers Of Cognitive Decline.
Funder
National Health and Medical Research Council
Funding Amount
$429,500.00
Summary
Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken wit ....Alzheimer's disease (AD) is a major cause of dementia in the elderly. As populations worldwide are living longer the prevalence of AD is predicted to rise markedly and in addition to the huge emotional burden on families the economic implications to the community at large is severe. Thus our aging veteran population and their spouses are particularly vulnerable to this devastating disease. Recent developments in AD research have resulted in a number of therapeutic strategies being undertaken with several of these now in phase 2 clinical trials. However for these treatments to be most effective early diagnosis is crucial. Currently, definite diagnosis is restricted to post-mortem examination of the brain for the presence of characteristic neuropathological features. This project proposes to identify individuals at high risk of developing cognitive decline leading to AD by using a battery of biochemical, genetic and neuropsychological markers. This study builds on our earlier work which followed a cohort of memory complainers and demonstrated that subjects in this group have lower cognitive scores and an increased frequency of the genetic risk factor, the e4 allele of apolipoprotein E. Follow up of this well studied cohort with more sensitive and extensive neuropsychological tests together with other genetic and biochemical markers will be important in identifying those risk factors that have positive predictive value for cognitive decline thereby contributing towards enhancing the therapeutic efficacy of current symptomatic and future drugs directed at the cause of AD.Read moreRead less
Predicting Health And Disease In Australian Men Over The Age Of 80 Years - The Health In Men Study
Funder
National Health and Medical Research Council
Funding Amount
$528,754.00
Summary
Australia is ageing rapidly but we still do not know whether the risk factors, such as health and lifestyle, that predict ill health in middle aged people, apply to people as they reach old age. This study of a large group of older men will examine the type and level of risk factors that apply to men aged beyond 75 years. It will not only determine rates of disability and mortality but also health service outcomes, including hospitalisation, and residential and community care usage.
Envisaging Citizenship: Australian Histories and Global Connections. This project aims to investigate the ways that visual images have defined, contested and advanced ideas of Australian citizenship and rights from European settlement to the present. Responding to the lack of a shared mainstream understanding of Australian citizenship, it looks beyond legal definitions to explore cultural and especially visual views of citizenship over time. Through collaboration with museum, media and education ....Envisaging Citizenship: Australian Histories and Global Connections. This project aims to investigate the ways that visual images have defined, contested and advanced ideas of Australian citizenship and rights from European settlement to the present. Responding to the lack of a shared mainstream understanding of Australian citizenship, it looks beyond legal definitions to explore cultural and especially visual views of citizenship over time. Through collaboration with museum, media and education sectors, it will provide a forward-looking and accessible public history, and utilise the potential of images to broaden contemporary debates about citizenship. Expected outcomes include a better public understanding of the pathways to citizenship, and enhanced engagement with Australian values and identity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101043
Funder
Australian Research Council
Funding Amount
$404,956.00
Summary
Tackling facial prejudice. This project aims to investigate individual differences in facial prejudice, a powerful psychological bias whereby people rely on inaccurate first impressions to guide key decisions, such as whom to trust. Utilising recent advances in electrophysiology, the project will develop a new neural marker of individual differences in facial impressions that lead to prejudice. The project expects to lead to insights into the link between visual perception and social behaviour, ....Tackling facial prejudice. This project aims to investigate individual differences in facial prejudice, a powerful psychological bias whereby people rely on inaccurate first impressions to guide key decisions, such as whom to trust. Utilising recent advances in electrophysiology, the project will develop a new neural marker of individual differences in facial impressions that lead to prejudice. The project expects to lead to insights into the link between visual perception and social behaviour, and to develop strategies to reduce facial prejudice given the pervasive influence it has on everyday life.Read moreRead less
In-vivo functional imaging of cone photoreceptors and ganglion cell axons. Can we project a movie on a human retina, and measure the response of photoreceptor cells and connected nerve tissue? This project aims to investigate a new method for visualization of the quickest responses in human cone photoreceptors and nerve cells after a visible stimulus. Expected outcomes of this project include a better understanding of the origins of responses to a stimulus and how cells in the retina communicate ....In-vivo functional imaging of cone photoreceptors and ganglion cell axons. Can we project a movie on a human retina, and measure the response of photoreceptor cells and connected nerve tissue? This project aims to investigate a new method for visualization of the quickest responses in human cone photoreceptors and nerve cells after a visible stimulus. Expected outcomes of this project include a better understanding of the origins of responses to a stimulus and how cells in the retina communicate. The scientific results will be helpful in a better understanding of the development of vision in the infant eye, to study peripheral vision in elite athletes and to quantify performance of virtual reality equipment for the military. The IP on the technology can be licensed or used for start-up company.Read moreRead less
Who may judge a book by its cover? This project aims to build a model of how and why people vary in their impressions of others and in the accuracy of these impressions. People readily form impressions of others from their faces and these impressions influence crucial decisions: election results, court case outcomes and partner choices. To build this model, the project will apply twin data and construct a psychometric test to measure variation in facial impressions. The research is expected to l ....Who may judge a book by its cover? This project aims to build a model of how and why people vary in their impressions of others and in the accuracy of these impressions. People readily form impressions of others from their faces and these impressions influence crucial decisions: election results, court case outcomes and partner choices. To build this model, the project will apply twin data and construct a psychometric test to measure variation in facial impressions. The research is expected to lead to insights into this aspect of social perception, and to identify the sources of atypical or inaccurate facial judgements. This has applications in health contexts (to identify social impairment) and in security contexts (for personnel selection).Read moreRead less
Old Atrocities, New Media: Terror Images and the Visual-Military Complex. This research centres on the relations between twenty-first century visual technologies and the age-old practice of the massacre-atrocity. It takes as its major case study the atrocities at the end of the war in Sri Lanka in 2009. The most graphic form of knowledge about these mass deaths and rapes was produced through digitally transmitted visual images. The research asks how new forms of recording and circulating images ....Old Atrocities, New Media: Terror Images and the Visual-Military Complex. This research centres on the relations between twenty-first century visual technologies and the age-old practice of the massacre-atrocity. It takes as its major case study the atrocities at the end of the war in Sri Lanka in 2009. The most graphic form of knowledge about these mass deaths and rapes was produced through digitally transmitted visual images. The research asks how new forms of recording and circulating images of atrocity, whether in the form of trophy photographs or other digital documents, shape the reception of, and responses to, atrocity. These questions are contextualised against a broader examination of the historical and evolving relations between visual media and atrocity images from the Holocaust to Abu Ghraib.Read moreRead less