Understanding the generation of hypothalamic sleep neurons. This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly inc ....Understanding the generation of hypothalamic sleep neurons. This Project aims to investigate the mechanisms controlling the formation of the sleep neurons in the hypothalamus. We all sleep, and normal sleep-wake cycles play a central role in our biology. The functional role of these sleep neurons in the mature brain are well established. However, how the neurons are generated during development is very poorly defined. This project aims to address this critical knowledge gap, and will greatly increase our understanding of how the development of this critical aspect of organismal function is orchestrated during development. This project will also develop bioinformatics tools with broad utility within the biosciences field and enhance the capacity for interdisciplinary international collaborations.Read moreRead less
Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be ....Old brain cells perform new tricks to allow life-long learning. In the brain, nerve cells transmit electrical signals more quickly and reliably when they are insulated. The insulating cells undergo small adaptive changes that speed up information transfer during learning, and the faster the electrical signal, the better the learning outcomes. This project aims to understand the signals that direct insulating cells to adapt and support life-long learning. In the longer term, this knowledge may be used to: develop interventions that improve learning and educational outcomes; counteract age-related memory decline and enable longer work force participation; develop strategies to circumvent the memory loss caused by brain diseases, or improve the design of computer hardware.Read moreRead less
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Network activity and the role of NMDA receptors in associative learning. The brain is the most complex machine we know, and its activity shapes every aspect our lives. Studies over decades using tools from molecular and cellular neuroscience and behavioural experiments have discovered the parts of the brain involved in learning and memory formation. Much is understood about the neural circuits that mediate learning but how memories are formed and stored are not understood. The aim of this proj ....Network activity and the role of NMDA receptors in associative learning. The brain is the most complex machine we know, and its activity shapes every aspect our lives. Studies over decades using tools from molecular and cellular neuroscience and behavioural experiments have discovered the parts of the brain involved in learning and memory formation. Much is understood about the neural circuits that mediate learning but how memories are formed and stored are not understood. The aim of this project is to understand learning and memory formation using a simple Pavlovian learning paradigm, fear conditioning. Using cutting-edge molecular tools we will label the circuits in the amygdala that mediate this learning and the nature of the memory trace. In the long term, these results may drive novel storage devices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100778
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Mapping the neural circuits that underlie emotional learning. This project aims to understand the precise neural circuits that mediate the formation of emotional memories. Recent findings have identified a novel complexity in these circuits and the goal of this proposal is to resolve the underlying mechanism that drives emotional memories. In detail, this project will combine state of the art dual- optical stimulation techniques combined with behaviour-dependent tagging of neurons to investigate ....Mapping the neural circuits that underlie emotional learning. This project aims to understand the precise neural circuits that mediate the formation of emotional memories. Recent findings have identified a novel complexity in these circuits and the goal of this proposal is to resolve the underlying mechanism that drives emotional memories. In detail, this project will combine state of the art dual- optical stimulation techniques combined with behaviour-dependent tagging of neurons to investigate the precise brain circuits linked to emotional learning, an approach that also allows knowledge transfer to other research fields. Expected outcomes and benefits of the project is a significant shift in our understanding of the neural mechanisms that underlie emotional learning.Read moreRead less
Novel role of RNA methylation in neuronal homeostasis. This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mec ....Novel role of RNA methylation in neuronal homeostasis. This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mechanistic insights into the molecular processes that control neuronal homeostatic responses. This will elucidate how neural plasticity and network stability are maintained, a process that is critical for our understanding of sensory processing, learning and memory throughout life.Read moreRead less
How does embryonic physiology shape the divergence of brain development? . Unlike placental mammals (humans, mice, dogs etc) marsupials give birth to very immature young that finalise development in the pouch. Despite this remarkable distinction in the major mammalian lineages, very little is known about how differing reproductive environments impact development and evolution. This project aims to explore how developing inside or outside a uterus impacts brain development in placental vs marsupi ....How does embryonic physiology shape the divergence of brain development? . Unlike placental mammals (humans, mice, dogs etc) marsupials give birth to very immature young that finalise development in the pouch. Despite this remarkable distinction in the major mammalian lineages, very little is known about how differing reproductive environments impact development and evolution. This project aims to explore how developing inside or outside a uterus impacts brain development in placental vs marsupial mammals. Expected outcomes include expanding theories of how different body systems are connected in development and evolution, understanding what aspects of marsupial development might be especially sensitive to variations in environment brought about by climate change and enhancing Australia’s research capabilities.Read moreRead less
Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that t .... Dynamic DNA structure states and memory formation. Activity-induced gene expression is central to neural plasticity, learning, and memory; however, the underlying mechanisms of these processes in the brain have yet to be fully resolved. The aim of this proposal is to obtain a deeper understanding of the functional relationship between genes and brain function. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and the formation of memory, it is hoped that the true nature of brain adaptation across the lifespan will be revealed. Findings which may then provide new opportunities to strengthen, maintain and optimise cognitive function.Read moreRead less
Temporal interactions of dorsal/ventral visual streams. This project aims to understand the temporal interactions between the dorsal and ventral visual streams that control skilled actions. The neural pathways for visual perception of objects may be distinct from those associated with movements towards the object, but the speed of activation and interactions of these two cortical visual streams have not been investigated. This project will use the temporal sensitivity of neuroscience brain imagi ....Temporal interactions of dorsal/ventral visual streams. This project aims to understand the temporal interactions between the dorsal and ventral visual streams that control skilled actions. The neural pathways for visual perception of objects may be distinct from those associated with movements towards the object, but the speed of activation and interactions of these two cortical visual streams have not been investigated. This project will use the temporal sensitivity of neuroscience brain imaging techniques (MEG, EEG, fMRI) to measure the real-time sequence of interactions between the two visual streams during goal-directed grasping. It intends to extend the most influential model of visual processing by discovering ‘when’ these pathways activate and interact. Such knowledge will affect delivery of social and commercial outcomes, by providing new directions for the rehabilitation of sensorimotor performance in many neurodevelopmental disorders, and by improving design of control systems for robotic effectors, prosthetic limbs, and more seamless human-machine interfaces.Read moreRead less
Defining novel neuroepigenetic pathways that influence learning and memory. This project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenet ....Defining novel neuroepigenetic pathways that influence learning and memory. This project aims to better understand the functional relationship between epigenetic mechanisms and regulatory RNAs in the brain and how they influence learning and the formation of memory. Activity-induced gene expression is central to neural plasticity, learning, and memory. However, efforts to elucidate the underlying mechanisms in the brain have not been fully resolved. By elucidating the full repertoire of epigenetic mechanisms in the brain during learning and memory formation, the findings of the project will be broadly applicable and create new opportunities for understanding the true nature of brain adaptation.Read moreRead less