Discovery Early Career Researcher Award - Grant ID: DE130100223
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Characterisation of visceral afferent spinal cord pathways. Sensory nerves in the gut wall are key mediators of chronic visceral pain. This project will characterise how sensory nerves supplying the bowel connect to the spinal cord and the spinal circuits mediating pain perception, providing information to identify sensory pathways underlying visceral pain.
Discovery Early Career Researcher Award - Grant ID: DE200101577
Funder
Australian Research Council
Funding Amount
$427,116.00
Summary
Microarchitectural attacks and JavaScript: threats and defences. This project aims to improve cybersecurity by identifying and mitigating vulnerabilities in Internet-connected computers. Expected outcomes of this project include novel techniques for protecting web browsers and cloud server, to prevent them from inadvertent leaks of private or sensitive information. This should provide significant benefits, such as reduced risk of cyberattacks and improved privacy for web users.
Discovery Early Career Researcher Award - Grant ID: DE120100304
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Biomimetic systems for species preservation and fertility restoration. Using a novel 3-D culture system the project will examine the biomechanics of ovary follicle and egg development in vitro, generating new knowledge with directly translatable research outcomes. In vitro egg production has implications for human fertility and threatened species preservation, significantly benefitting health and biodiversity in Australia.
Discovery Early Career Researcher Award - Grant ID: DE120100907
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The brain, maths and space: their interaction in health and disease. This project investigates how thinking about numbers affects how we think about the space that surrounds us - and vice versa. Investigations of commonalities in the neural and cognitive processing of space and numbers may lead to the development of innovative therapies for people suffering from attentional disorders after brain damage.
Discovery Early Career Researcher Award - Grant ID: DE140101530
Funder
Australian Research Council
Funding Amount
$372,744.00
Summary
Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotr ....Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100620
Funder
Australian Research Council
Funding Amount
$378,000.00
Summary
Mechanisms of controlled gene expression in cells and organisms. The goal of this project is to reveal the nature of a cellular mechanism that has a major influence on gene expression in all eukaryotic cells. How gene expression is controlled is of fundamental importance to all life forms. The project plans to develop molecular tools that enable the visualisation and interrogation of this gene regulatory mechanism in live cells, tissues and whole organisms. The outcomes are anticipated to lead t ....Mechanisms of controlled gene expression in cells and organisms. The goal of this project is to reveal the nature of a cellular mechanism that has a major influence on gene expression in all eukaryotic cells. How gene expression is controlled is of fundamental importance to all life forms. The project plans to develop molecular tools that enable the visualisation and interrogation of this gene regulatory mechanism in live cells, tissues and whole organisms. The outcomes are anticipated to lead to an essential understanding of how cells respond to physiological and environmental cues by coordinating changes in gene expression, and to provide potential avenues towards manipulation for pharmaceutical, agricultural and biotechnology purposes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100549
Funder
Australian Research Council
Funding Amount
$373,220.00
Summary
Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interfe ....Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interference and low resolution Raman spectroscopies. These optical signals will be converted into barcodes containing several levels of information, which will be at the base of this versatile point-of-care test. The obtained results will be implemented in a computerised database to improve current cardiac disease diagnosis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101449
Funder
Australian Research Council
Funding Amount
$463,399.00
Summary
How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options ....How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options for responding to, and potentially mitigating the impacts of environmental change on the mammalian reproductive system.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100750
Funder
Australian Research Council
Funding Amount
$395,106.00
Summary
Associative learning and fluid intelligence: Computational and neurogenetic analyses. This project investigates genetic contributions to associative learning, one of our most fundamental abilities. Associative learning allows us to navigate in our environment, predict future events and make appropriate decisions. Electrophysiological measures will be used to study learning processes precisely and to investigate their relationship to polymorphisms in genes that regulate neural function. This rese ....Associative learning and fluid intelligence: Computational and neurogenetic analyses. This project investigates genetic contributions to associative learning, one of our most fundamental abilities. Associative learning allows us to navigate in our environment, predict future events and make appropriate decisions. Electrophysiological measures will be used to study learning processes precisely and to investigate their relationship to polymorphisms in genes that regulate neural function. This research will further understanding of the mechanisms that generate individual differences in learning ability and will have applications for educational techniques and behavioural interventions.Read moreRead less