Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100115
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploi ....High-temperature probes for investigating phase transitions and reaction kinetics in thin films, nanostructured materials and biomaterials. This infrastructure for high temperature surface analysis and in-situ diagnostics as a function of temperature and gas environments will enhance Australia's capabilities in creating new materials for devices that will meet needs in medical, communications, environmental and security applications. The facility will enable researchers to understand and exploit interfacial phenomena and to tailor processing-microstructure-composition correlations, so as to design new materials with the best performance possible. Probes with unique capabilities will measure surface morphology, optical properties, elemental composition and crystallographic phase.The facility will be the first in Australia to offer a comprehensive study of structure and properties at high temperature.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989123
Funder
Australian Research Council
Funding Amount
$575,000.00
Summary
Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside ....Spark Plasma Sintering (SPS) Facility for Advanced Materials Processing. The establishment of the first Spark Plasma Sintering (SPS) facility would significantly enhance Australia's capacity in manufacturing of advanced materials, especially the more sophisticated and specialized materials, which is a National Research Priority. This facility will benefit a large number of researchers and projects in Australia's premier research organisations and will also meet the needs of organisations outside the consortium. It will allow Australian researchers to remain at the leading edge of research and enhance collaborations in advanced materials nationwide. The successful outcomes of these activities will underpin the advancement in many areas of research and technology developments in the country.Read moreRead less
Crustal Growth in the Northern Tasmanides. The Australian and Queensland governments have invested over $3 million to undertake deep crustal seismic imaging in northern Queensland, providing an extensive new geophysical dataset capable of modelling crustal architecture and geological evolution to unprecedented levels. However, such models will remain untested unless the data is groundtruthed by analysis of rocks at the surface, providing a geological framework for extrapolation into the deep Ea ....Crustal Growth in the Northern Tasmanides. The Australian and Queensland governments have invested over $3 million to undertake deep crustal seismic imaging in northern Queensland, providing an extensive new geophysical dataset capable of modelling crustal architecture and geological evolution to unprecedented levels. However, such models will remain untested unless the data is groundtruthed by analysis of rocks at the surface, providing a geological framework for extrapolation into the deep Earth. The framework critically describes when and how crustal blocks were assembled, and the integrated information will generate evolutionary 3D models that will substantially improve mineral exploration targeting in the region.Read moreRead less
Molecular Regulation Of Metabolism And Body Composition By Ski Via Crosstalk With Nuclear Hormone Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$558,441.00
Summary
Obesity is a common and burdensome health problem in the community which leads to diabetes and heart disease. A number of factors, including hormones play important roles in determing risk of obesity. This study proposes to investigate whether the Ski gene which is a regulatory factor for many hormones affects metabolism in transgenic mouse models of altered Ski function. The proposed studies may identify Ski as a target for therapy for obesity and improvement in sketal muscle metabolism.
ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry ....ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry. The Centre will also play a leading role in the undergraduate and postgraduate training of future geoscientists. The concentration of internationally recognised researchers in the Centre will ensure it maintains its premier position in the international ore deposit research arena.Read moreRead less
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Four dimensional lithospheric evolution and controls on mineral system distribution in Neoarchean to Paleoproterozoic terranes. This project will resolve important questions about the links between the evolution and preservation of continents and important mineral deposits in Australia and West Africa between 2.7 and 1.8 billion years ago. The results will improve the understanding of a key period of Earth history and make a major contribution to mineral exploration.