EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to defin ....From exploration to mining: new geological strategies for sustaining high levels of copper production from the Mount Isa district. Mineral production at the Mount Isa copper and Ernest Henry copper-gold mines is worth more than $ 1 billion per year and this has underpinned the northern Queensland economy for a number of years. These resources are being depleted at a high rate, and no significant new discoveries have been made in over a decade. This project will provide some of the tools to define new resources for the next generation, ensuring the prosperity of the region and bolstering the Australian economy. The timing is critical given the long lead time between discovery and production (in the order of 5 to 10 years). If successful the research may have major financial impacts at local, regional and national scales. It may also improve mine safety.Read moreRead less
Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant ....Fundamental experimental and modelling studies of slag/matte/metal/gas systems in support of sustainable copper smelting and converting technologies. Australia is in the midst of a sustained increase in demand for its mineral resources that is leading to expansion in production and major capital investments across the industry sector. Most of the primary production of copper metal in Australia takes place through the use of high temperature smelting technologies. New technologies and significant changes to existing smelting technologies are currently underway; driven by the need to improve both productivity and environmental performance. This research partnership will provide important fundamental information about the complex chemistries of these high temperature processes. This project will assist these process improvements and will provide competitive advantage to Australian industry.Read moreRead less
A new methodology for the measurement of transition metals ions in complex, high temperature oxide systems relevant to non-ferrous metal production. Complex multi-component molten oxide phases, known commonly as slags, are used in the high temperature production and refining of metals. The slag systems of commercial interest contain transition metals species, such as, Fe2+, Fe3+. Each of these species behaves as if it were a separate chemical component. Researchers at the University of Queensla ....A new methodology for the measurement of transition metals ions in complex, high temperature oxide systems relevant to non-ferrous metal production. Complex multi-component molten oxide phases, known commonly as slags, are used in the high temperature production and refining of metals. The slag systems of commercial interest contain transition metals species, such as, Fe2+, Fe3+. Each of these species behaves as if it were a separate chemical component. Researchers at the University of Queensland have developed a new methodolgy, which enables the concentrations of these transition metal ions to be measured.
These types of measurements cannot be made with any of the techniques currently in use. The study will provide data on high temperature slags in a number of industrially and scientifically important systems. This approach will be applicable to a wide range of chemical systems in the fields of extractive metallurgy, materials science and geology; systems which could not previously be characterised.Read moreRead less
Improvements in the pyrometallurgical processing of nickel oxide and laterite ores at QNI Yabulu, North Queensland. The QNI Yabulu operation in Queensland is an important supplier of nickel and cobalt metals to the export market. The company is planning to expand the scale of the operations but is faced with two important sustainability issues. One is the recent changes to the European regulations that require very low levels of residual nickel oxide in the nickel metal product. The second issue ....Improvements in the pyrometallurgical processing of nickel oxide and laterite ores at QNI Yabulu, North Queensland. The QNI Yabulu operation in Queensland is an important supplier of nickel and cobalt metals to the export market. The company is planning to expand the scale of the operations but is faced with two important sustainability issues. One is the recent changes to the European regulations that require very low levels of residual nickel oxide in the nickel metal product. The second issue relates to ensuring the supply and improved recovery of nickel and cobalt from oxide-based ores. Further fundamental scientific information is required to provide improved understanding of the complex chemical reactions occurring during the high temperature treatment of these materials, and to guide improvements in product quality, recovery and process efficiencyRead moreRead less
ADVANCED THERMODYNAMIC AND PROCESS MODELS FOR HIGH TEMPERATURE METAL SMELTING TECHNOLOGIES - A COLLABORATIVE RESEARCH PROGRAM IN PYROMETALLURGY. This 5-year ARC Linkage project developed by the Pyrometallurgy Research Centre, UQ brings together several consortia of major mineral companies in a genuinely collaborative way to address a range of complex technical problems associated with the high temperature chemical processing of minerals and metals.
The UQ research team brings new state-of-the- ....ADVANCED THERMODYNAMIC AND PROCESS MODELS FOR HIGH TEMPERATURE METAL SMELTING TECHNOLOGIES - A COLLABORATIVE RESEARCH PROGRAM IN PYROMETALLURGY. This 5-year ARC Linkage project developed by the Pyrometallurgy Research Centre, UQ brings together several consortia of major mineral companies in a genuinely collaborative way to address a range of complex technical problems associated with the high temperature chemical processing of minerals and metals.
The UQ research team brings new state-of-the-art research methodologies, and experimental and computer modelling techniques to provide scientifically important research outcomes which can be used by the industry. The research program will provide fundamental thermodynamic and physical property information on the complex chemical systems encountered in industrial processes, powerful computer models, and applied research outputs for industry. The project will also importantly provide research training in the field pyrometallurgy, deliver competitive advantage to the Australian mineral industry and bring economic benefits particularly to regional Australia.
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Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Numerical modelling of deformation partitioning and its role in metamorphism, tectonism and mineralization. Targeting blind mineralization is the biggest problem facing the Australian mining industry. The modelling developed in this project will integrate deformation, fluid and chemical processes and provide a means for understanding the deformation partitioning that localizes epigenetic ore regionally as well as along portions of large-scale structures. Applying this to known ore deposits may ....Numerical modelling of deformation partitioning and its role in metamorphism, tectonism and mineralization. Targeting blind mineralization is the biggest problem facing the Australian mining industry. The modelling developed in this project will integrate deformation, fluid and chemical processes and provide a means for understanding the deformation partitioning that localizes epigenetic ore regionally as well as along portions of large-scale structures. Applying this to known ore deposits may delineate adjacent plus regionally distributed zones where the deformation event responsible for mineralization is locally present at sufficient intensity to form ore. This would allow targeted deep drilling in ground with no ore close to the surface saving millions in drilling costs and dramatically increasing the financial viability of this industry. Read moreRead less
Post-GWAS Functional Characterisation Of Breast Cancer Susceptibility Loci
Funder
National Health and Medical Research Council
Funding Amount
$764,632.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.