Discovery Projects - Grant ID: DP160101874

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP160101874

Funding Status
Closed

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Funded Activity Summary

Understanding how pore-forming proteins punch holes in membranes. This project aims to unravel missing molecular details of how a major superfamily of proteins is able to drill holes in cell membranes. Animals, plants, fungi and bacteria all use pore-forming proteins as cell-killing weapons of mass destruction. Despite their lethal nature and their roles in infection and immunity, how these proteins work remains enigmatic. Project outcomes could reveal novel mechanisms general to these essential proteins and provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, the knowledge gained may prove useful in the engineering of membrane pores as highly specific sensors for a variety of molecules with nanotechnology and biotechnology applications.

Funded Activity Details

Start Date: 01-01-2016

End Date: 31-12-2020

Funding Scheme: Discovery Projects

Funding Amount: $620,500.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Expanding Knowledge in the Biological Sciences | Structural Biology (incl. Macromolecular Modelling)

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