Discovery Projects - Grant ID: DP180100040

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP180100040

Funding Status
Active

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Funded Activity Summary

How do MACPF/CDC proteins punch giant holes in lipid membranes? This project aims to study the Membrane Attack Complex (MAC)/Perforin-like/Cholesterol Dependent Cytolysins (MACPF/CDC) family which form unusually large holes in membranes. This project aims to define the exact molecular shape of a monomer in comparison with the exact molecular shape of the pore of the MACPF/CDC family. This project will also provide new information about the intermediate steps in pore formation. This will have major benefits to agribusiness and nanotechnology applications.

Funded Activity Details

Start Date: 04-06-2018

End Date: 31-12-2022

Funding Scheme: Discovery Projects

Funding Amount: $416,111.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Characterisation of Biological Macromolecules | Biochemistry and Cell Biology | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Control of Plant Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments | Expanding Knowledge in the Biological Sciences |

Other Keywords

Biochemistry and Cell Biology | Characterisation of Biological Macromolecules | Control of Plant Pests, Diseases and Exotic Species in Farmland, Arable Cropland and Permanent Cropland Environments | Expanding Knowledge in the Biological Sciences | Receptors and Membrane Biology | Structural Biology (incl. Macromolecular Modelling)

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