Discovery Projects - Grant ID: DP200101152

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP200101152

Funding Status
Active

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Funded Activity Summary

Understanding how an old heart gets stiff. Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness and to determine whether this process governs normal aging of the heart. This work will advance understanding of how heart function is determined and reveal how the human heart changes with normal aging.

Funded Activity Details

Start Date: 28-02-2020

End Date: 27-02-2023

Funding Scheme: Discovery Projects

Funding Amount: $440,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology - Systems | Cell Physiology | Cardiology (incl. Cardiovascular Diseases) | Medical Physiology |

ANZSRC Socio-Economic Objective (SEO)

Health Related to Ageing | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences

Other Keywords

Animal Physiology - Systems | Cardiology (incl. Cardiovascular Diseases) | Cell Physiology | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Health Related to Ageing | Medical Physiology

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