Discovery Projects - Grant ID: DP210101752

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP210101752

Funding Status
Active

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Funded Activity Summary

Understanding peptide bond formation in non-ribosomal peptide biosynthesis. This project aims to uncover the origins of selectivity exhibited by the biosynthetic machinery that produces non-ribosomal peptides through advancing our understanding of how the central peptide synthesis domain functions. This project intends to generate new knowledge about peptide biosynthesis using a highly interdisciplinary approach and essential tools that have been developed. The anticipated outcomes of this project will be an enhanced understanding of the structural basis for substrate selection exhibited during peptide synthesis, revealing the specificity code of these key domains. This knowledge is vital for future efforts to reengineer such biosynthetic peptide assembly lines to produce new bioactive peptides.

Funded Activity Details

Start Date: 01-01-2021

End Date: 31-12-2023

Funding Scheme: Discovery Projects

Funding Amount: $360,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Proteins and Peptides | Characterisation of Biological Macromolecules | Medicinal and Biomolecular Chemistry | Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Biological Sciences |

Other Keywords

Characterisation of Biological Macromolecules | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Medicinal and Biomolecular Chemistry | Proteins and Peptides | Structural Biology (incl. Macromolecular Modelling)

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