Linkage Projects - Grant ID: LP160100705

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/LP160100705

Funding Status
Closed

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Funded Activity Summary

Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities. Polymeric nanoparticles for delivery of siRNA: mechanisms and opportunities. This project aims to improve the delivery of small interfering RNA (siRNA) molecules using self-assembling nanoparticles. A series of biological barriers, at tissue and intracellular levels, limit the distribution of siRNA, and prevent these macromolecules from fulfilling their potential as therapeutic agents. Limited penetration of tissues restricts access to target cells, and intracellular enzymes often degrade the small proportion of the dose that is taken up by cells. The project intends to investigate new mechanisms to overcome these biological barriers using novel chemical approaches. This research is expected to have major health and economic outcomes, nationally and internationally.

Funded Activity Details

Start Date: 22-11-2016

End Date: 31-12-2019

Funding Scheme: Linkage Projects

Funding Amount: $515,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nanomedicine | Pharmacology and Pharmaceutical Sciences | Pharmaceutical Sciences | Nanochemistry and Supramolecular Chemistry

ANZSRC Socio-Economic Objective (SEO)

Human Pharmaceutical Products not elsewhere classified | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences |

Other Keywords

Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Medical and Health Sciences | Human Pharmaceutical Products not elsewhere classified | Nanochemistry and Supramolecular Chemistry | Nanomedicine | Pharmaceutical Sciences | Pharmacology and Pharmaceutical Sciences

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