New roles for the spleen tyrosine kinase in antibody-independent renal injury.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1002079

Funding Status
Closed

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Funded Activity Summary

This study investigates the novel hypothesis that a particular cell activation pathway (called Syk) is important not only in antibody-based kidney disease, but that it also plays a previously unrecognised role in other forms of antibody-independent kidney disease. Drugs that inhibit the Syk pathway are in clinical development for treatment of diseases such as arthritis. Hence, a positive outcome of this project could lead to the use of Syk inhibitors in many different types of kidney disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $574,890.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nephrology and Urology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

experimental antiGBM glomerulonephritis | fibrosis | glomerular inflammation | glomerulosclerosis | immunopathology | kidney disease | kinase inhibitors | renal interstitial fibrosis | signalling pathways

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