Relaxin therapy reverses large artery remodelling and stiffening in aged and hypertensive models

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004235

Funding Status
Closed

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Funded Activity Summary

Hypertension and/or ageing result in morphological changes in large arteries with increased stiffness, which impacts negatively to cardiac function and increases the risk of cardiovascular disease. Currently there is no drug that can specifically and rapidly reverse the changes in large arteries. We will study a peptide hormone relaxin as a promising candidate drug in this setting. Our recent study strongly indicate the effectiveness of relaxin in softening stiffened large arteries.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $444,973.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ageing | ageing population | arterial stiffness | cardiovascular risk factors | hypertension | relaxin | therapy

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