Molecular characterisation of TRAIL-regulated signal transduction pathways and their role in the development, persistence, and exacerbation of allergic airways disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1011153

Funding Status
Closed

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Funded Activity Summary

Molecules that promote the development, persistence, and exacerbation of asthma are only poorly defined. We have discovered a novel signalling pathway that is activated in the airway wall during asthma. Blocking a molecule that activates this pathway ameliorated asthma in mice. We now want to identify all the important components of this pathway and therapeutically modulate them to prevent the development, persistence, and exacerbation of asthma.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $637,035.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

allergen-induced inflammation | asthma | asthma exacerbation | asthma therapy | lung inflammation | molecular mechanisms | respiratory viruses | rhinovirus

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