Role of STAT5 in defining lifespan in mouse models

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1025094

Funding Status
Closed

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Funded Activity Summary

We seek to elucidate the molecular basis for the extended lifespan seen in the Methuselah mouse, the longest lived mouse model of ageing. This mouse lacks the receptor for growth hormone, and we have identified a major gene-regulating protein activated by the growth hormone receptor as correlating with lifespan. This project seeks to establish if this protein does indeed regulate lifespan, and to determine how it does this, particularly in relation to metabolism of toxins and free radicals.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $547,216.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

JAK/STAT pathway | free radical damage | growth hormone | healthy ageing | molecular gerontology | mortality | toxins

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