Paget's disease of bone associated Sequestosome 1/p62 mutations in autophagy-mediated processes and bone resorption

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1027932

Funding Status
Closed

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Funded Activity Summary

Paget’s disease of bone (PDB) is a common, chronic bone disorder characterized by focal lesions of increased bone degradation initiated by giant overactive osteoclasts. Subsequent bone formation is irregular, resulting in bones that are structurally weak. Genetic mutations are a common cause of PDB in Caucasians. Understanding the genetic mutations and their regulation on bone cells may lead to the discovery of a new drug target for the treatment of PDB.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $474,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Orthopaedics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Paget's disease of bone | autophagy | bone | osteoclast | osteoclastogenesis

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