Structural Basis of Substrate Recognition by the Membrane-Associated E3 Ubiquitin Ligases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1030902

Funding Status
Closed

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Funded Activity Summary

Membrane-associated E3 ubiquitin ligases control cellular levels of important immunoregulatory molecules and occur in both host- and virus-encoded forms. Target selectivity maps to the transmembrane domains of ligases and their substrates in a little-studied mode of intramembrane molecular recognition. Our goal is to determine the physical basis of this interaction by establishing which sequences drive the association and providing atomic-resolution structures of the membrane-embedded complexes.

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $415,244.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Herpes simplex virus (HSV) | membrane trafficking | nuclear magnetic resonance (NMR) | structural immunology | ubiquitination

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