Investigating the pathogenesis of motor neuron disease using zebrafish models

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1034816

Funding Status
Closed

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Funded Activity Summary

Amyotrophic lateral sclerosis (ALS) causes the progressive death of motor nerves. Most ALS patients die within 2-5 years of disease onset. We recently identified mutations that cause ALS in the genes TDP-43 and FUS. We aim to develop fish that carry these mutations. We will monitor and test this fish to establish whether they develop similar symptoms and features to ALS. If so, this new fish model will be available for investigating the biology of the disease and for evaluating treatments

Funded Activity Details

Start Date: 01-01-2012

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $554,881.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

animal model | motor neuron disease (MND) | neurobiology | neurodegenerative disorders | zebrafish

Related Links

ACN 633 798 857