Assessment of microcirculatory impairment in reperfused acute myocardial infarction by invasive coronary hemodynamic measurements and cardiac magnetic resonance imaging: modulation by exenatide

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1052960

Funding Status
Closed

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Funded Activity Summary

This study aims to assess the health of small blood vessels of the heart muscle during and following a heart attack by measuring blood flow with a pressure wire and with cardiac magnetic resonance imaging. Small blood vessels within the heart muscle may become injured due to lack of oxygen and white cell activation during a heart attack. This study investigates the effect of a new agent, exenatide, on small blood vessels and white cells and determines whether it might lessen the degree of damage to heart muscle and small blood vessels.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $388,752.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

acute myocardial infarction (AMI) | cardioprotection | coronary blood flow | magnetic resonance imaging (MRI) | microcirculation | neutrophils | reperfusion injury

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