Inducible caspase 9 suicide gene to improve the safety of donor T cell addback after haploidentical stem cell transplantation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1053135

Funding Status
Closed

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Funded Activity Summary

In bone marrow transplantation, donor immune cells are important for fighting cancer cells and infections but can also attack healthy tissues, causing graft-versus-host disease (GVHD). We will use gene technology to insert a safety switch called inducible capase 9 (iCasp9) into the donor immune cells which will make them susceptible to an otherwise non-toxic chemical. This will make it safer to boost the recipients’ immunity because these cells can be rapidly eliminated if GVHD occurs.

Funded Activity Details

Start Date: 01-01-2013

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $566,232.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cell therapy | gene transfer | graft versus host disease (GVHD) | haematopoietic stem cell transplantation | immune reconstitution

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