Investigating secondary effects of BACE1 inhibition, a promising therapy for Alzheimer's disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1058672

Funding Status
Closed

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Funded Activity Summary

Synapses transfer information between neurons in the brain. In Alzheimer’s disease (AD), synapse loss results in dementia therefore it is imperative that any potential therapeutic drugs do not inadvertently cause further synapse loss. Drugs aimed at blocking production of toxic protein fragments in AD might have adverse secondary effects on synapse development and function. This research will determine whether this is the case and inform new therapeutic approaches aimed at minimizing side effects.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $700,672.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | dendrites | enzyme inhibitors | neurodegenerative disorders | neurodevelopmental disorders | neuronal plasticity | synapse formation

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