Using Nkx2-5 knock-in mouse models to understand complex cardiac diseases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1069710

Funding Status
Closed

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Funded Activity Summary

The most common cause of postnatal mortality is heart defects associated with mutation in transcriptional factors, of which NKX2-5 is the master gene. NKX2-5 is also involved in cardiac dysfunction in adults. We developed a unique mouse genetic approach that mimics human disease to study the mechanism behind this gene function. Our work paves the way to more efficient forecast, counseling and treatment strategies, reducing the socio-economic burden of congenital heart disease our community.

Funded Activity Details

Start Date: 01-01-2014

End Date: 01-01-2016

Funding Scheme: Project Grants

Funding Amount: $611,340.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiac dysfunction | disease mechanisms | heart development | mouse genetics | transcriptional regulation

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