Structural and functional alterations of sarcomeric proteins in reperfused myocardium

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/107272

Funding Status
Closed

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Funded Activity Summary

Coronary artery disease remains the major cause of mortality for the adult population in our society. Despite the advances of coronary artery bypass surgery and medical treatment for reperfusion of occluded coronary arteries, the problem of impaired pump function of the heart remains a major obstacle. Although blood flow can be restored to the jeopardised heart muscle by either clot dissolving drugs, balloon angioplasty, or coronary artery surgery, the heart muscle may not regain pump function for days to weeks after the event. This delayed recovery of pump function, known as myocardial stunning, can lead to heart failure and slow down a patient's recovery from heart surgery or heart attack. The cause of this myocardial stunning is unknown. We suggest that stunning results from damage to essential proteins in the contractile apparatus of the heart, which requires a prolonged time period for repair. This project aims to identify the site and extent of protein damage occurring in the heart following interruption and subsequent restoration of cardiac blood flow. In concert with this, we seek to determine the mechanism of protein damage. The findings of this project should allow us to subsequently investigate new treatment approaches for acute pump dysfunction in patients with ischaemic heart disease.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $271,786.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nutrigenomics and personalised nutrition

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

angina pectoris | calcium | cardiac disease | coronary artery bypass surgery | myocardial contractility | myocardial infarction | myocardial ischaemia and reperfusion injury | myofilament proteins | oxygen radicals

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