Restoring neuroprotective sphingosine 1-phosphate signalling in Alzheimer’s Disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1100626

Funding Status
Closed

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Funded Activity Summary

Our research team has recently shown that a vital signalling lipid called S1P is lost from the brains of people who are in the early stages of developing Alzheimer's Disease. S1P protects brain cells against toxic insults that cause Alzheimer's Disease. This project will investigate how loss of S1P sensitizes people to the development of Alzheimer’s Disease, and the effectiveness of clinical drugs that restore S1P signals in protecting against Alzheimer’s Disease and restoring brain function.

Funded Activity Details

Start Date: 01-01-2016

End Date: 01-01-2019

Funding Scheme: Project Grants

Funding Amount: $857,656.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | G-protein coupled receptors | apolipoprotein E | lipid biochemistry | neurodegenerative disorders

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