TRAFFICKING OF MEMBRANE SULFATE TRANSPORTERS IN THE KIDNEY

Funded Activity Summary

Many diseases such as diabetes, cystic fibrosis, Alzheimer's and Parkinson's, results from a defect in the intracellular trafficking of specific membrane proteins. One important family of membrane proteins are the renal sulphate transporters, NaSi-1 and sat-1. They are two important proteins that control body sulphate homeostasis. Sulphate in the body is essential for cell matrix formation and cartilage-bone development and growth. Trafficking defects in these proteins can lead to changes in serum sulphate levels, which results in softening of the bones, insufficient cartilage development, and changes in many metabolic processes. Using techniques of molecular and cellular biology, we aim to identify the precise the mechanisms that control the trafficking of these proteins in cells. This will enable us to determine how these proteins functions in both the normal and diseased states, which is currently unknown.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2003

Funding Scheme: NHMRC Project Grants

Funding Amount: $211,527.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cartilage/bone disorder | Epithelial trafficking | Hypersulphaturia | Hyposulphataemia | Phosphorylation and glycosylation | Post-transcriptional regulation | Protein-protein interactions | Renal reabsorption disorder | Renal sulphate membrane transporters | Sulphate metabolism disorder

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