Functional studies on a neuroprotective activity of the amyloid precursor protein of Alzheimer s disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/145761

Funding Status
Closed

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Funded Activity Summary

Alzheimer's disease is a major health problem of the elderly. With our aging population living longer, this presents enormous economic and social pressures. Research into the mechanism of Alzheimer's disease is therefore of immediate importance. In this study we are trying to determine the relationship between proteins involved in the disease process. In particular we are studying the amyloid precursor protein (APP). APP has both therapeutic as well as disease causing actions. It gives rise to the toxic amyloid peptide Abeta which is responsible for disease. However APP can also inhibit Abeta toxicity thus controlling cell death. We are studying how APP is able to modulate the neurotoxic activity of Abeta. These studies will identify key aspects of the disease pathway and hopefully lead to treatment strategies.

Funded Activity Details

Start Date: 01-01-2001

End Date: 01-01-2001

Funding Scheme: NHMRC Project Grants

Funding Amount: $160,475.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer's Disease | Amyloid | Cognition | Dementia | Neurodegeneration | Neuroprotection | Neurotoxicity

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