Structure and Function of Receptors for IgG (FcgammaR)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/181625

Funding Status
Closed

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Funded Activity Summary

This reasearch project is attempting to understand one of the most important mechanisms of resistance to infectious disease and one of the most important mechanisms of induction of destructive inflammation in autoimmune disease. These studies will define how blood proteins called antibodies, antibodies bind to the surface of white blood cells via proteins called Fc receptors that activate these white blood cells. Under normal circumstances this system provides resistance to infection but is involved in some of the most debilitating diseases, including allergies, bleeding disorders called thrombocytopoenias, inflammation of blood vessels, vasculitis, as well as aspects of rheumatoid arthritis. The successful conclusion of this project will result in knowledge that will enable the development of more effective and highly specific therapeutic approaches to the treatment of disease and a better understanding of the functioning of the immune system.

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2004

Funding Scheme: NHMRC Project Grants

Funding Amount: $905,280.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Clinical microbiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antibody | Arthritis rheumatoid | Autoimmune diseases | Fc receptors | Immune mediated inflammation | Immunity to infection | Immunology | Platelets | Rheumatology | Thrombocytopaenia

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