Metabotropic glutamate receptors: pharmacological studies of receptor subtypes in neuronal injury.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/194320

Funding Status
Closed

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Funded Activity Summary

Glutamate is the major transmitter of excitatory information in the mammalian brain. Disruption of glutamate-mediated signaling between brain cells results in high extracellular levels of glutamate which is toxic to neurones. A recently discovered family of signal transducers, the metabotropic glutamate receptors, has been found to be localized on neurones and is switched on by these toxic glutamate levels. The roles of these metabotropic glutamate receptors in neurotoxicity is essentially unexplored and is the topic under investigation in this project. How their activation affects cellular signaling switch on will be investigated to gain an understanding of the roles metabotropic glutamate receptors play in acute brain injury (eg stroke) and chronic neurodegenerative conditions (eg Huntington's chorea and Alzheimer's disease).

Funded Activity Details

Start Date: 01-01-2002

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $145,770.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - carbohydrates

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

G proteins | apoptosis of neurons | excitatory amino acids | excitotoxicity | glial-neuron relationship | glutamate receptors | neuro-excitatory side-effects | neurodegenerative and age-related diseases | neuropharmacology | neuroprotective drugs to minimise death after stroke

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