Bring out your dead - how does defective apoptotic cell clearance by tingible body macrophages lead to the activation of self-reactive B cells in SLE?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/2003662

Funding Status
Status not available

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Funded Activity Summary

Good housekeeping is critical to the day-to-day running of the immune system. In the case of the germinal centre, a key structure where plasma cells are generated, the ability to clear away dead and dying cells is critical because failure to do so can lead to the spillover of cellular waste and debris into the follicle where they can activate harmful B cells to make autoantibodies and cause disease. Understanding how this happens can lead to new ways to target and treat autoimmune diseases.

Funded Activity Details

Start Date: 01-01-2020

End Date: End date not available

Funding Scheme: Ideas Grants

Funding Amount: $721,597.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

autoantibodies | autoimmune disease | b cells | macrophages

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