Investigation of Cancer Predisposition in Heterozygous Carriers of the ATM

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/241925

Funding Status
Closed

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Funded Activity Summary

Individuals with the human genetic disorder ataxia-telangiectasia are prone to cancer development and so also are their parents and relatives (carriers) who have one defective copy of the gene. This is a multisystem disease that is also characterized by neurodegeneration, immunodeficiency, infertility and extreme sensitivity to radiation. This project is designed to generate a mouse model of this disease to investigate cancer susceptibility in carriers of the defective gene. The specific mutation to be introduced into the mouse has been described in a patient with breast cancer and it has been shown to interfere with the normal function of the ATM protein. The mouse model is expected to reflect closely the human disease and will provide the opportunity to monitor heterozygous carriers for the development of cancer. This model is expected to confirm the observations in humans and provide a resource to understand susceptibility to develop cancer. The model will also address the issue of exposure to low dose radiation and risk of developing cancer.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-01-2007

Funding Scheme: NHMRC Project Grants

Funding Amount: $822,750.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology And Carcinogenesis

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Cancer | Cre/lox mice | DNA damage | ataxia-telangiectasia | genetic disease | immunodeficiency | ionizing radiation | neurodegenerative disease

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