Transcriptional control of programmed cell death

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/399303

Funding Status
Closed

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Funded Activity Summary

Programmed cell death (PCD), also known as apoptosis, plays a fundamental role in cell and tissue homeostasis and its misregulation is implicated in many human diseases. Many hormones control PCD but their mechanisms of action remain poorly understood. As hormones, in particular the steroid hormones, are directly linked to the pathogenesis of many forms of cancer, including breast, prostate and ovarian cancer, some of the most common malignancies afflicting the society, it is important to study the mechanism of hormonal control of apoptosis in order to identify components of the regulatory apparatus. Identification of precise factors that regulate PCD will not only provide basic understanding of hormone-controlled PCD, but any novel factors involved in the control of cellular levels of death activators or death inhibitors are potential targets for anticancer drug development. This proposal is based on our ongoing studies, which combine the powerful biochemical and cellular approaches with the in vivo studies in vinegar fly (Drosophila) to address complex issues that are often difficult to pursue by the direct use of mammalian systems. We believe that the results from this study will provide novel insights into the mechanisms of hormone-regulated control of PCD and how these control mechanisms are disrupted under pathological conditions.

Funded Activity Details

Start Date: 01-01-2006

End Date: 01-01-2008

Funding Scheme: NHMRC Project Grants

Funding Amount: $509,267.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Drosophila | cancer cell biology | caspases | cell death/apoptosis | control of gene expression | developmental disorders | gene expression | hormone-dependent cancer | steroid hormone action | steroid hormones

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