Dissecting the function of heparanase in inflammatory disease using genetic tissue-specific ablation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/471424

Funding Status
Closed

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Funded Activity Summary

This project aims to define the role of the enzyme heparanase in a number of important diseases, namely Inflammatory-autoimmune diseases such as multiple scelorosis and rheumatiod arthritis, and the growth and spread of cancer. Heparanase has been implicated for many years in promoting these diseases however its precise contribution has not beed defined. These studies will provide definitive information whether heparanase is a valid therapuetic target in these important disease settings.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $580,848.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Autoimmune disease | Cell invasion | Gene targeting | Heparanase | Inflammation | Inflammatory disease | Leukocyte migration | Multiple sclerosis | Tumour progression | Vascular disease

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