The tumour suppressor Lgl in the regulation of cell signaling, proliferation and apoptosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509020

Funding Status
Closed

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Funded Activity Summary

Cancer is a disease that affects 1-3 people at some point in their lifetime. Therefore, understanding what causes cancer is of major importance to medical science. This proposal focuses on a group of tumour suppressors, Scrib-Dlg-Lgl, which act in a common pathway to regulate cell polarity (cell shape) and proliferation. We have shown that Lgl also regulates cell death. This proposal focuses on understanding the mechanism by which Lgl regulates the cell proliferation and death machinery.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $534,871.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Tumour suppressor | cancer and related disorders | cancer: mechanisms of growth, invasion, metastases | cell death-apotosis | cell proliferation | proliferative disorders | signalling pathways

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