The function of polarity regulators in cancer

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/509336

Funding Status
Closed

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Funded Activity Summary

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble promotes cancer using a combination of tissue culture studies and a newly established mouse model. Understanding how this new pathway can regulate tumour development may provide novel targets for therapeutic intervention in cancer.

Funded Activity Details

Start Date: 01-01-2008

End Date: 01-01-2010

Funding Scheme: NHMRC Project Grants

Funding Amount: $573,557.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

RAS Transformation | breast cancer | cancer and related disorders | cancer biology | cancer: mechanisms of growth, invasion, metastases | epithelial biology | invasion and metastases | mouse models of cancer | tumour suppressors

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