Sphingosine kinase as a target therapeutic for obesity induced insulin resistance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/526608

Funding Status
Closed

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Funded Activity Summary

Obesity is linked to the development of insulin resistance and diabetes, which represent a significant health issue in Australia. A number of factors contribute to the development of insulin resistance, including defective fatty acid metabolism. This study proposes to investigate whether manipulating sphingosine kinase, a key enzyme in lipid metabolism, affects the development of insulin resistance. These studies may identify novel targets for the treatment of insulin resistance and diabetes.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $450,390.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Inflammation | Insulin resistance | Metabolism | Muscle lipids | Obesity | Skeletal muscle | Type 2 diabetes

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