Ghrelins novel neuroprotective effects in Parkinsons disease are mediated by AMP-activated protein kinase (AMPK).

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/546131

Funding Status
Closed

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Funded Activity Summary

Studies show that body mass index, midlife adiposity and diabetes are associated with Parkinson's disease (PD). During obesity there is a dramatic change in nutritional information, such as hormones, sugars and fats, carried in the blood. This proposal explores how this altered nutritional information in obesity kills the brain cells associated with PD. It will examine how ghrelin, a metabolic hormone inversely related to obesity, influences and protects brain cell activity in models of PD.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2011

Funding Scheme: NHMRC Project Grants

Funding Amount: $400,885.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical infection agents (incl. prions)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Body weight regulation | Diabetes | Neurological disorders | Obesity | Parkinson's disease | effects of energy metabolism on Parkinson's disease | metabolic neuroscience | neuroendocrinology | role of obesity in the pathogenesis of neurological disease

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