Development of Novel Anti-Inflammatory Agents

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/546243

Funding Status
Closed

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Funded Activity Summary

There is an unmet need for safe and effective anti-inflammatory drugs. Because P38 MAPK intracellular signalling modulates multiple pro-inflammatory cytokine actions, it appears to be an ideal candidate pathway. P38 inhibitors have been limited by their toxicity within hepatocytes. The aim of this program therefore is to develop agents with enhanced P38 MAPK inhibitory effects as well as reduced liver toxicity based on known structure activity relationships.

Funded Activity Details

Start Date: 01-01-2009

End Date: 01-01-2009

Funding Scheme: NHMRC Development Grants

Funding Amount: $200,600.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical biochemistry - amino acids and metabolites

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Anti-inflammatory agents, or drugs | Chronic heart failure | Chronic inflammation | Drug development | Drug discovery | Inflammatory diseases | Protein kinases | Rheumatoid arthritis

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